{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Lv J"],"pubmed_abstract":["Luteolin is a flavonoid widely found in plants, including vegetables, botanical drugs, and fruits. Owing to its diverse pharmacological activities, such as anticancer, oxidative stress protection, anti-inflammatory, and neuron-preserving effects, luteolin has attracted attention in research and medicine. Luteolin exhibits therapeutic effects on various pulmonary disease models through multiple molecular mechanisms; these include inhibition of activation of the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-κB) and MAPK signaling pathways, as well as the promotion of regulatory T cell (Treg) function and enhancement of alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation and oxidative stress responses). Luteolin has therapeutic effects on chronic obstructive pulmonary "],"journal":["Frontiers in pharmacology"],"pagination":["1535555"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11861102"],"repository":["biostudies-literature"],"pubmed_title":["Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases."],"pmcid":["PMC11861102"],"pubmed_authors":["Lv J","Huang D","Zou K","Xiao L","Luo Z","Song X"],"additional_accession":[]},"is_claimable":false,"name":"Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases.","description":"Luteolin is a flavonoid widely found in plants, including vegetables, botanical drugs, and fruits. Owing to its diverse pharmacological activities, such as anticancer, oxidative stress protection, anti-inflammatory, and neuron-preserving effects, luteolin has attracted attention in research and medicine. Luteolin exhibits therapeutic effects on various pulmonary disease models through multiple molecular mechanisms; these include inhibition of activation of the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-κB) and MAPK signaling pathways, as well as the promotion of regulatory T cell (Treg) function and enhancement of alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation and oxidative stress responses). Luteolin has therapeutic effects on chronic obstructive pulmonary ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-03T23:44:20.059Z","creation":"2025-04-03T23:44:20.059Z"},"accession":"S-EPMC11861102","cross_references":{"pubmed":["40012626"],"doi":["10.3389/fphar.2025.1535555"]}}