biostudies-literatureBarbeta EInstituto de Salud Carlos III27https://www.ebi.ac.uk/biostudies/studies/S-EPMC11861844biostudies-literatureUnknown15(1)<h4>Background</h4>The relative contribution of the different components of mechanical power to mortality is a subject of debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the relative impact of each of the components of mechanical power on mortality in a well-characterized cohort of patients with COVID-19-induced acute respiratory failure undergoing invasive mechanical ventilation. This is a secondary analysis of the CIBERESUCICOVID project, a multicenter observational cohort study including fifty Spanish intensive care units that included COVID-19 mechanically ventilated patients between February 2020 and December 2021. We examined the association between mechanical power and its components (elastic static, elastic dynamic, total elasticAnnals of intensive careMechanical power is not associated with mortality in COVID-19 mechanically ventilated patients.PMC11861844ISCIII(ISCIIISara Borrell 2021: CD21/00087Miguel Servet 2020: CP20/00041COV20/00110Moral-Parras PAdell-Serrano BSancho SBastida LPVal ETrefler SFurro ALeon MFerrer RCliment CFerrando CPlanelles GPMantellini CLPeis EMBlancas RHermoso DCCachafeiro LPous APGonzalez JOcon MRiera JBadia MBueno LNieto MTRoche-Campo FGracia MPJimenez JFMFernandez-Barat LCastellvi AGomez JMSarinena MTPrados JArijon IELago ALLopez JPravia OBde Castro FRClar LRubio JFernandez EMMGonzalez CGOssa SPinol-Tena ARuiz CRMartin MCAgrifoglio ARubio EPTormos ACilloniz CTrujillano JAlvarez JILVan der Hofstadt Martin-Montalvo MBarbera CServia LAlbaiceta GMKiarostami KBofill NBustamante-Munguira ECabello MASocias LBustamante-Munguira JWarrington TVPujol AVilas MDRAlcaraz-Serrano VVengoechea JTamayo LAnon JMSoliva LBarreiros CMoreno CDCano SGMColl NRDelgado MCMEspina LFMaseda EOrtega ALazaro ASTrenado JMontejo-Gonzalez JCValdivia LJGumucio-Sanguino VDMartinez ICastillo MLGGoma GBarbeta EGarcia FMartinez MFernandez PCMartinez AGarcia BBardi TDiaz MJBarberan JCasal VGPenuelas OAlegre CSagredo VCarbajales CSagastume AGUrrelo-Cerron LCaballero JCodina JCarvalho SIbarz MLoza-Vazquez ABigas JAlvarez SGarcia RNJDot IPerez PGordo FSpeziale CForcadell-Ferreres EForin EFranco NArrieta MPagliarani PFernandez SCBarbena LAdrio SVTognetti DLorente JACano IGomez SVicente PMAznar MMGarcia LCContreras SHerran-Monge RBalsera BEstella AGiraudo PECastro PSalinas RNMendiluce RMSanchez MAvila RCPenasco Yde Gonzalo-Calvo DDegracia ASDel Busto Martinez CHerrera NMRuiz LVVidal JVieiro MTBConde PVidal PGallego ETorres MSole-Violan JBou RNde la Torre MDCBarbe FBoado MVNovo MAHerraiz ASerra-Fortuny MPerez-Garcia FTorres AMonclou JMarcos PGarcia JABCortes PVSanchez-Giron GRCortes MLBFernandez JBadia JRMiralles MRRicart PRodriguez DMPrieto EGSanchez ABalan ASegade PBAmaya-Villar RSanchez-Miralles ANicolas JMVila-Vilardel CAldecoa CCarbonell NMorales DRuiz AAMonjo TFNaya GMHuerta AGalban CLaguna DPMarin-Corral JSantacoloma BCIBERESUCICOVID Project investigators (COV20/00110, ISCIII)Figueras AMontserrat NRedruello CGYang HLopez-Gavin ASerra LGuzzardella AYang MDiaz YBarroso MCasacuberta-Barbera NJaner MTParrilla FCatalan-Gonzalez MZapatero AIglesias SMurua PRCastella MMotos APaz ESGabarrus ADiaz EJuan MDMRodriguez LVallverdu MGuerrero DMSaera MBVallverdu JBoado MCanton-Bulnes MLRodriguez AAngel Jde Pablo Sanchez RAyestaran JIFernandez CEMBlandino ARodriguez SUbeda AAndrea RCeccato AVilanova JMunoz-Bermudez RDe Mendoza DVazquez NPensado MSJimenez GMasclans JRMiralbes MAguilera LLopez ARfalseMechanical power is not associated with mortality in COVID-19 mechanically ventilated patients.<h4>Background</h4>The relative contribution of the different components of mechanical power to mortality is a subject of debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the relative impact of each of the components of mechanical power on mortality in a well-characterized cohort of patients with COVID-19-induced acute respiratory failure undergoing invasive mechanical ventilation. This is a secondary analysis of the CIBERESUCICOVID project, a multicenter observational cohort study including fifty Spanish intensive care units that included COVID-19 mechanically ventilated patients between February 2020 and December 2021. We examined the association between mechanical power and its components (elastic static, elastic dynamic, total elastic2025-01-01T00:00:00Z2025 Feb2026-07-15T08:45:15.529Z2026-07-01T03:12:33.318ZS-EPMC118618443999875110.1186/s13613-025-01430-6