biostudies-literatureChaki MMinisterio de Ciencia, Innovación y Universidades, Spanish GovernmentResearch Support Plan of the University of JaénGrant for the Recalibration of the Spanish University System (Margarita Salas)Junta de Andalucíae70076https://www.ebi.ac.uk/biostudies/studies/S-EPMC11862108biostudies-literatureUnknown34(3)Nitro-fatty acids (NO₂-FAs) are novel molecules resulting from the interaction of unsaturated fatty acids and nitric oxide (NO) or NO-related molecules. In plants, it has recently been described that NO₂-FAs trigger a powerful antioxidant and defense response against stressful situations, the induction of the heat-shock response (HSR), and they exert their signaling function mainly through a reversible post-translational modification called nitroalkylation. Catalase (CAT) is a key antioxidant enzyme for the control of the hydrogen peroxide (H₂O₂) levels generated by environmental oxidative stress. The data presented in this study provide novel information on the role of NO₂-FAs in modulating the antioxidant activity of catalase 2 (CAT2Protein science : a publication of the Protein SocietyNitro-fatty acids-mediated nitroalkylation modulates fine-tuning catalase antioxidant function during salinity stress in plants.PMC11862108R.01/01/2023R.01/01/2022PAIDI BIO286PID2022-142973NB-I00PID2020-117774GA-I00R.02/10/2020Chaki MAranda-Cano LPedrajas JRSanchez-Calvo BLopez-Jaramillo FJBarroso JBBegara-Morales JCPadilla MNValderrama RfalseNitro-fatty acids-mediated nitroalkylation modulates fine-tuning catalase antioxidant function during salinity stress in plants.Nitro-fatty acids (NO₂-FAs) are novel molecules resulting from the interaction of unsaturated fatty acids and nitric oxide (NO) or NO-related molecules. In plants, it has recently been described that NO₂-FAs trigger a powerful antioxidant and defense response against stressful situations, the induction of the heat-shock response (HSR), and they exert their signaling function mainly through a reversible post-translational modification called nitroalkylation. Catalase (CAT) is a key antioxidant enzyme for the control of the hydrogen peroxide (H₂O₂) levels generated by environmental oxidative stress. The data presented in this study provide novel information on the role of NO₂-FAs in modulating the antioxidant activity of catalase 2 (CAT22025-01-01T00:00:00Z2025 Mar2025-04-05T14:39:12.71Z2025-04-05T14:39:12.71ZS-EPMC118621084000723610.1002/pro.70076