{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Xia Y"],"pubmed_abstract":["The precise placement of thioester bonds into sequence-controlled polymers remains a grand challenge. Here, we demonstrate the versatile synthesis of sequence-controlled polymers from the step polymerization of cyclic thioanhydrides (A), diacrylates (B), and diols/diamines (C). In addition to easily accessible diverse monomers, the method is metal-free/catalyst-free, atom-economical, and wide in monomer scope, yielding 107 polymers with >90% yields and weight-average molecular weights of up to 175.4 kDa. The obtained polymers contain ABAC-type repeating units and precisely distributed in-chain thioester and ester (and amide) groups. The chemoselectivity of the polymerization is revealed by density functional theory calculations. The polymer library exhibits considerably tunable performance"],"journal":["Nature communications"],"pagination":["1974"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11862183"],"repository":["biostudies-literature"],"pubmed_title":["Precise placement of thioester bonds into sequence-controlled polymers containing ABAC-type units."],"pmcid":["PMC11862183"],"pubmed_authors":["Xia Y","Gu C","Zhang X","Zhang C","Sun Y","Wang J","Shao T"],"additional_accession":[]},"is_claimable":false,"name":"Precise placement of thioester bonds into sequence-controlled polymers containing ABAC-type units.","description":"The precise placement of thioester bonds into sequence-controlled polymers remains a grand challenge. Here, we demonstrate the versatile synthesis of sequence-controlled polymers from the step polymerization of cyclic thioanhydrides (A), diacrylates (B), and diols/diamines (C). In addition to easily accessible diverse monomers, the method is metal-free/catalyst-free, atom-economical, and wide in monomer scope, yielding 107 polymers with >90% yields and weight-average molecular weights of up to 175.4 kDa. The obtained polymers contain ABAC-type repeating units and precisely distributed in-chain thioester and ester (and amide) groups. The chemoselectivity of the polymerization is revealed by density functional theory calculations. The polymer library exhibits considerably tunable performance","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-05T14:39:08.083Z","creation":"2025-04-05T14:39:08.083Z"},"accession":"S-EPMC11862183","cross_references":{"pubmed":["40000662"],"doi":["10.1038/s41467-025-57208-8"]}}