{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["333(8)"],"submitter":["Dark P"],"pubmed_abstract":["<h4>Importance</h4>For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.<h4>Objective</h4>To determine whether decisions based on assessment of CRP or PCT safely results in a reduction in the duration of antibiotic therapy.<h4>Design, setting, and participants</h4>A multicenter, intervention-concealed randomized clinical trial, involving 2760 adults (≥18 years), in 41 UK National Health Service (NHS) intensive care units, requiring critical care within 24 hours of initiating intravenous antibiotics for suspected sepsis and likely to continue antibiotics for at least 72 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and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.<h4>Objective</h4>To determine whether decisions based on assessment of CRP or PCT safely results in a reduction in the duration of antibiotic therapy.<h4>Design, setting, and participants</h4>A multicenter, intervention-concealed randomized clinical trial, involving 2760 adults (≥18 years), in 41 UK National Health Service (NHS) intensive care units, requiring critical care within 24 hours of initiating intravenous antibiotics for suspected sepsis and likely to continue antibiotics for at least 72 hours.<h4>Interventi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-06T17:44:16.365Z","creation":"2026-06-03T03:10:36.725Z"},"accession":"S-EPMC11862976","cross_references":{"pubmed":["39652885"],"doi":["10.1001/jama.2024.26458"]}}