biostudies-literatureUnknown333(8)Dark P<h4>Importance</h4>For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.<h4>Objective</h4>To determine whether decisions based on assessment of CRP or PCT safely results in a reduction in the duration of antibiotic therapy.<h4>Design, setting, and participants</h4>A multicenter, intervention-concealed randomized clinical trial, involving 2760 adults (≥18 years), in 41 UK National Health Service (NHS) intensive care units, requiring critical care within 24 hours of initiating intravenous antibiotics for suspected sepsis and likely to continue antibiotics for at least 72 hours.<h4>InterventiJAMA682-693https://www.ebi.ac.uk/biostudies/studies/S-EPMC11862976biostudies-literatureBiomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.PMC11862976Woods LWaterman SSingleton JDunombe AHalliday FYoung DLane PFlanagan RAmiruddin NEbrahim HDavie TMartir GBurgess LAbu-Hijleh SGordon ACDavid HJutsum FHarwood JMceachan LWylie KStickley JStorey IFinn SBailey LHooper ABarnsley MBarnsley LSwindells LCalder VAndrew GRoche LWhite JWaugh VLone NWhite SHoward LMcCoy ASummers JAttwood BParez JCorr HParker RJTurner KMcCulloch CCornell SWhite DGallagher HGulati ACarling NHandley TRoss ARegan SGallagher LTodd JMorton BReilly LDoverman KBeekes MOmer HMcKenna EJose SLythgoe CManetas-Stavrakakis NQuinn GKaur DOlsen FHamad SHoughton MClare RDooley NPursglove MWelters IDCarter HCarter JDeacon BManes SLinhartova LBurke JWalton LBromage NQuilty FDoonan RAmamio MOram SSharma SEllis KHollick DSharma JGarcia PBalasubramaniam MVian-Michael ADunn LDooley CHarkett SMistry DMistry BBano SKhakh MClutton-Brock TAlmafreji IMcNamee JMohyddin UBabio-Galan MSheriff JGellamucho MHowson-Wells HSmyth DRidley MPatrick-Heselton JBickerton MJohnson EMilton-White SCrooks NGates SKarangoda DPhillips SAtkin SPhillips MRedgate SMatovu EBoxall JKefala KMcMullan RWorner RDennis AHowcroft CLone NIWhiteley SSinclair SAdeyemo TCooper SSalah SMulcahy MToth-Tarsoly PBurn SMellish LParkin EFoggett SJasiewicz JWalmsley NMahiya AWynne ESinger MLaha STurley CAgravante KWalsh TSHays CGillies MAssi ALloyd MLloyd LCook SLlewellyn NCasey AHerbert DFaulkner BShaw DO'Kane MPurvis SSukumaian AJaved MCole CAllock RThomas ECole NThomas MMouncey PRThomas PNorris MOgg BLaurenson IThomas ZYuan JXPattterson AJagannathan VMohamed TYKenny LKay DWood GMcMullen SBaker HKnight KDavison ALaw DSampson JRichmond KRoberts JAkeroyd LSturmey GClement IYates GGabriel CLopez Martinez MMiddleton DClarke SRichards GWatson JHossain ASingh JGrice MZapata Martinez MADodd AClayton JCKamangu BMcNamee JJParekh DBates MManazar UMcewen NMcCullagh IJBion JRea NCurrie HScargill JBircham SMcauley DWilding LHenning JYates DHarvey DShrestha TO'Neill AWebster RRatnakumar AShoremekun AWard KWard JMcCormack CWard LNorman CGavina LZuriaga-Alvaro AStevenson MDKimachia SFerris PStorey-Waters BFriar ZMarshall KJi CQuiambao MSmeaton JMarshall CMulholland PSmith LMaren DFelton TWMacGowan ASmith RCockcroft CColfar JSmith WHadfeild JYu LMPerry RPurdy ODonaldson DDrummond AWilliams KMcNeil HCTaylor SWilliams AWilliams CAkinyoola OFerguson LTaylor HPrentice JPerkins GBelsham MCasbon MTaylor CWright CPatel JWinnard SDengate JReyes AMitchinson VRowbottom LRatcliffe LGibson BBriton KFilipe HHewison CHague AMorrison RLynch CFonseca AJWilliams SBirch SGibson HLatham SHamilton SMacdonald LMccaig WDenmade CMacdonald JMathew GGhuman BKHorner DGeorge SDonnelly ABlackmore HMurrant HSubudhi CPKGoundry SBean SGupta RLubbock SSpruce EAntil PRoy AReeves EBorzomato JGreen JFerguson RGould RAuer ZTurner-Bone IPendlebury JLatham DBowes AGurov VPeters CSavage JMcNeill GThompson CThompson AMcNeil MSernicola ECinquina ZThompson JAshby HTreus ERostron ADuce HCarlson GMcCullagh INance AGill RBaidoo ACamplejohn AGoff EEvans SPerrin SO'Connor GParker RWatkin DAzad RConstable SGibbins AWilcox RMcIver WMooradun MParipoorani DPaisley CPajak SEvans JLiggett SEvans EWilkinson THugill KMcCrone PJones JMaharajh AJones LBercades GNesbitt JJones RLewis GMacCallum NMorris AGoode CHayes KMashangombe LKitching MHarold JAlexander PDGHuang YJHolden JBeddows SZaki ADearden JBrealey DDe Neef MWalsh TWatts SBurns TYeung JMingo SRikunenko RMcGRADY MBorislavova BSellers KVallotton NCollins EReid KVipond LPagett KMoncayo Nieto OLRajasekar JWilby ECollins JWilson PVernazza JShelton JClark GClark LHudson CADAPT-Sepsis CollaboratorsTalbot AClark ABoulton AButt LMConnor SMoody LMartin MButler LRichardson MBallinger SHughes AGyamerah BSellick AFarina SEdwards KHabib MHorton LDavies MNevels NGresty JTully RPLawton TMcGowan NBrammer LPearce JClark SSaba MPerkins GDMcGuigan PBland AGendall ELee STaylor DCLee JLowsby RKaura HThomson ACzarniak EHass IMaliaykal CMadanapalli Raghunath SChu CPugh JHalsall LRostron AJSimoes FSalada SVeiga CMelody TButler AMower CCoward SPrice LAdams CLoughlin RKitchener SBawa SAdams MWilson CSedgwick JPratley ASimpson SRogerson KKelsey MMowatt CMkandhla AMeredith MVeenith TCarroll NYoung KKBarber SMcAuley DFBarclay LRees AMcKeeman GBrown BConstantino MStephens AHellyer TPPakou GBannard-Smith JTeoh PCStefaniak MFernandez Roman JPriestley GReda ENaisbitt JTrott SGrieveson SBurt KWillis HPoole RLGarg ISolkar SHope DGriffith DCaxton APark DDuff COkotete OLong KCope AMostoles LDark PAdeeb MCope RKing IAjonu CSheridan CBonner SNaisbitt MJSimpspm JRothwell JBlessen CSpivey MDelaney JBaddeley AClayton JHabeichi DWFuller LQasim MWhitehouse TCrossan JLuck GRobinson ABangash MFord DLall RfalseBiomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.<h4>Importance</h4>For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.<h4>Objective</h4>To determine whether decisions based on assessment of CRP or PCT safely results in a reduction in the duration of antibiotic therapy.<h4>Design, setting, and participants</h4>A multicenter, intervention-concealed randomized clinical trial, involving 2760 adults (≥18 years), in 41 UK National Health Service (NHS) intensive care units, requiring critical care within 24 hours of initiating intravenous antibiotics for suspected sepsis and likely to continue antibiotics for at least 72 hours.<h4>Interventi2025-01-01T00:00:00Z2025 Feb2026-06-06T17:44:16.365Z2026-06-03T03:10:36.725ZS-EPMC118629763965288510.1001/jama.2024.26458