biostudies-literatureUnknown13Nakajima A<h4>Objective</h4>An interim analysis of postmarketing surveillance reported the safety and efficacy of elobixibat, a laxative medication that inhibits the ileal bile acid transporter, at 4 weeks in approximately 1000 patients with chronic constipation in Japan. However, its long-term safety and efficacy in elderly patients remain unclear. This study aimed to conclude and report the final analysis of postmarketing surveillance, including 52-week safety and efficacy profiles in a clinical practice setting, using approximately 3000 patients.<h4>Methods</h4>The overall survey period spanned from June 2018 to May 2022. Observation periods were set at 4 weeks (4-week treatment period) and 52 weeks (52-week treatment period). Adverse drug reactions and efficacy outcomes, including defecation freSAGE open medicine20503121251321659https://www.ebi.ac.uk/biostudies/studies/S-EPMC11863239biostudies-literatureA multicenter, postmarketing surveillance of elobixibat in patients with chronic constipation in Japan: A final analysis report.PMC11863239Shimada YUmeyama MNakajima AArai YHigashikawa MfalseA multicenter, postmarketing surveillance of elobixibat in patients with chronic constipation in Japan: A final analysis report.<h4>Objective</h4>An interim analysis of postmarketing surveillance reported the safety and efficacy of elobixibat, a laxative medication that inhibits the ileal bile acid transporter, at 4 weeks in approximately 1000 patients with chronic constipation in Japan. However, its long-term safety and efficacy in elderly patients remain unclear. This study aimed to conclude and report the final analysis of postmarketing surveillance, including 52-week safety and efficacy profiles in a clinical practice setting, using approximately 3000 patients.<h4>Methods</h4>The overall survey period spanned from June 2018 to May 2022. Observation periods were set at 4 weeks (4-week treatment period) and 52 weeks (52-week treatment period). Adverse drug reactions and efficacy outcomes, including defecation fre2025-01-01T00:00:00Z20252025-04-03T23:44:13.29Z2025-04-03T23:44:13.29ZS-EPMC118632394001276210.1177/20503121251321659