biostudies-literatureFerguson ELCalifornia Cancer Research ProgramNIA NIH HHSRobert Wood Johnson Foundation, the Wayne and Gladys Valley Foundation, The Ellison Medical Foundation, and by the Kaiser Permanente Community Health ProgramThe Community Benefit Program, Kaiser Permanente Northern CaliforniaNIH HHSe14575https://www.ebi.ac.uk/biostudies/studies/S-EPMC11863358biostudies-literatureUnknown21(2)<h4>Introduction</h4>We evaluated the independent associations between high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels with Alzheimer's disease and related dementias (ADRD).<h4>Methods</h4>Among 177,680 members of Kaiser Permanente Northern California who completed a survey on health risks, we residualized TGs and HDL-C conditional on age, sex, and body mass index. We included these residuals individually and concurrently in Cox models predicting ADRD incidence.<h4>Results</h4>Low (hazard ratio [HR] 1.06, 95% confidence interval [CI] 1.02-1.10) and high quintiles (HR 1.07, 95% CI 1.03-1.12) of HDL-C residuals were associated with an increased risk of ADRD compared to the middle quintile. Additional adjustment for TGs attenuated the association with high HDL-C (HR Alzheimer's & dementia : the journal of the Alzheimer's AssociationIndependent associations of high-density lipoprotein cholesterol and triglyceride levels with Alzheimer's disease and related dementias.PMC11863358T32AG049663-06A15-P30AG07297299-86883RF1AGO69259Risch NZimmerman SCMeyers TJWhitmer RAGilsanz PFerguson ELGlymour MMWang JChoi MOni-Orisan AHoffmann TJSchaefer CAJiang CKrauss RMfalseIndependent associations of high-density lipoprotein cholesterol and triglyceride levels with Alzheimer's disease and related dementias.<h4>Introduction</h4>We evaluated the independent associations between high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels with Alzheimer's disease and related dementias (ADRD).<h4>Methods</h4>Among 177,680 members of Kaiser Permanente Northern California who completed a survey on health risks, we residualized TGs and HDL-C conditional on age, sex, and body mass index. We included these residuals individually and concurrently in Cox models predicting ADRD incidence.<h4>Results</h4>Low (hazard ratio [HR] 1.06, 95% confidence interval [CI] 1.02-1.10) and high quintiles (HR 1.07, 95% CI 1.03-1.12) of HDL-C residuals were associated with an increased risk of ADRD compared to the middle quintile. Additional adjustment for TGs attenuated the association with high HDL-C (HR 2025-01-01T00:00:00Z2025 Feb2025-04-03T23:45:07.861Z2025-04-03T23:45:07.861ZS-EPMC118633584000891410.1002/alz.14575