biostudies-literatureBowers MInnovate UKHorizon EuropeCicely Saunders InternationalNational Institute for Health and Care Research Applied Research Collaboration South London (NIHR ARC SL) at King's College Hospital NHS Foundation Truste13716https://www.ebi.ac.uk/biostudies/studies/S-EPMC11865637biostudies-literatureUnknown16(2)<h4>Background</h4>Cancer cachexia has substantial impacts on people's quality of life. There is no current gold standard treatment, but the complex pathophysiology of cachexia suggests that a multitargeted and individualised treatment approach is needed. We aimed to evaluate the extent to which multicomponent interventions have targeted the key features of cachexia and been tailored to individuals, and differential effects on quality of life.<h4>Methods</h4>We conducted a systematic review of multicomponent interventions for adults with cancer cachexia. We searched four databases, two clinical trial registers and MedRxiv on 20 June 2024. Intervention components were classified by intervention category (nutritional, exercise/physical activity, pharmacological and psychosocial), cachexia feJournal of cachexia, sarcopenia and muscleMulticomponent Interventions for Adults With Cancer Cachexia: A Systematic Review.PMC1186563710, 047, 799101057043Maddocks MLaird BJAPetrasso CMcLuskie AHigginson IJBayly JBowers MfalseMulticomponent Interventions for Adults With Cancer Cachexia: A Systematic Review.<h4>Background</h4>Cancer cachexia has substantial impacts on people's quality of life. There is no current gold standard treatment, but the complex pathophysiology of cachexia suggests that a multitargeted and individualised treatment approach is needed. We aimed to evaluate the extent to which multicomponent interventions have targeted the key features of cachexia and been tailored to individuals, and differential effects on quality of life.<h4>Methods</h4>We conducted a systematic review of multicomponent interventions for adults with cancer cachexia. We searched four databases, two clinical trial registers and MedRxiv on 20 June 2024. Intervention components were classified by intervention category (nutritional, exercise/physical activity, pharmacological and psychosocial), cachexia fe2025-01-01T00:00:00Z2025 Apr2025-07-13T03:04:23.524Z2025-04-07T09:14:36.555ZS-EPMC118656374001245110.1002/jcsm.13716