{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(2)"],"submitter":["Cefis M"],"funding":["Fonds de recherche du Quebec Sante","Natural Sciences and Engineering Research Council of Canada","Canadian Institutes of Health Research"],"pubmed_abstract":["Aging-related muscle atrophy and weakness contribute to loss of mobility, falls, and disability. Mitochondrial dysfunction is widely considered a key contributing mechanism to muscle aging. However, mounting evidence positions physical activity as a confounding factor, making unclear whether muscle mitochondria accumulate bona fide defects with aging. To disentangle aging from physical activity-related mitochondrial adaptations, we functionally profiled skeletal muscle mitochondria in 51 inactive and 88 active men aged 20-93. Physical activity status confers partial protection against age-related decline in physical performance. Mitochondrial respiration remains unaltered in active participants, indicating that aging per se does not alter mitochondrial respiratory capacity. Mitochondrial r"],"journal":["Cell reports. Medicine"],"pagination":["101968"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11866497"],"repository":["biostudies-literature"],"pubmed_title":["Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca<sup>2+</sup> handling across the adult lifespan in men."],"pmcid":["PMC11866497"],"pubmed_authors":["Aubertin-Leheudre M","Marcangeli V","Gaudreau P","Robitaille R","Granet J","Huang Q","Gouspillou G","Hammad R","Trumpff C","Belanger M","Cefis M","Leduc-Gaudet JP","Morais JA","Picard M"],"additional_accession":[]},"is_claimable":false,"name":"Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca<sup>2+</sup> handling across the adult lifespan in men.","description":"Aging-related muscle atrophy and weakness contribute to loss of mobility, falls, and disability. Mitochondrial dysfunction is widely considered a key contributing mechanism to muscle aging. However, mounting evidence positions physical activity as a confounding factor, making unclear whether muscle mitochondria accumulate bona fide defects with aging. To disentangle aging from physical activity-related mitochondrial adaptations, we functionally profiled skeletal muscle mitochondria in 51 inactive and 88 active men aged 20-93. Physical activity status confers partial protection against age-related decline in physical performance. Mitochondrial respiration remains unaltered in active participants, indicating that aging per se does not alter mitochondrial respiratory capacity. Mitochondrial r","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-07-15T08:51:19.639Z","creation":"2025-04-07T07:50:27.862Z"},"accession":"S-EPMC11866497","cross_references":{"pubmed":["39933528"],"doi":["10.1016/j.xcrm.2025.101968"]}}