{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["134(3)"],"submitter":["Wang C"],"pubmed_abstract":["<h4>Background</h4>Chronic neuropathic pain generally has a poor response to treatment with conventional drugs. Sympathectomy can alleviate neuropathic pain in some patients, suggesting that abnormal sympathetic-somatosensory signaling interactions might underlie some forms of neuropathic pain. The molecular mechanisms underlying sympathetic-somatosensory interactions in neuropathic pain remain obscure.<h4>Methods</h4>Lumbar sympathectomy was performed in spared nerve injury (SNI) mice or rats, and the up-down method was used to measure the mechanical paw withdrawal threshold. Dorsal root ganglia (DRG) injection and perfusion were used to deliver virus or drugs. Methylated RNA immunoprecipitation sequencing, RNA-sequencing, and immunoelectron microscopy were used to identify neurotransmitt"],"journal":["British journal of anaesthesia"],"pagination":["804-816"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11867076"],"repository":["biostudies-literature"],"pubmed_title":["Sprouting sympathetic fibres release CXCL16 and norepinephrine to synergistically mediate sensory neuronal hyperexcitability in a rodent model of neuropathic pain."],"pmcid":["PMC11867076"],"pubmed_authors":["Li C","Liu M","Wang C","Di A","Feng X","Liang Z","Wei M","Fan H","Xu T","Xin W","Wu Y","Liu F","Dong B"],"additional_accession":[]},"is_claimable":false,"name":"Sprouting sympathetic fibres release CXCL16 and norepinephrine to synergistically mediate sensory neuronal hyperexcitability in a rodent model of neuropathic pain.","description":"<h4>Background</h4>Chronic neuropathic pain generally has a poor response to treatment with conventional drugs. Sympathectomy can alleviate neuropathic pain in some patients, suggesting that abnormal sympathetic-somatosensory signaling interactions might underlie some forms of neuropathic pain. The molecular mechanisms underlying sympathetic-somatosensory interactions in neuropathic pain remain obscure.<h4>Methods</h4>Lumbar sympathectomy was performed in spared nerve injury (SNI) mice or rats, and the up-down method was used to measure the mechanical paw withdrawal threshold. Dorsal root ganglia (DRG) injection and perfusion were used to deliver virus or drugs. Methylated RNA immunoprecipitation sequencing, RNA-sequencing, and immunoelectron microscopy were used to identify neurotransmitt","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-22T18:52:11.685Z","creation":"2025-04-06T02:39:10.896Z"},"accession":"S-EPMC11867076","cross_references":{"pubmed":["39848871"],"doi":["10.1016/j.bja.2024.10.019"]}}