{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["147(8)"],"submitter":["Yan SS"],"pubmed_abstract":["1,2-Amino-difunctionalization reactions of alkenes allow the efficient introduction of different functional groups and the rapid construction of valuable functionalized amines. In this respect, we report a copper-catalyzed 1,2-amino-alkoxycarbonylation of unactivated alkenes with CO and alkylamine precursors in the presence of a Lewis acid additive. The novel protocol allows direct access to valuable β-amino acid derivatives from easily available starting materials. The presented methods feature high chemo- and regioselectivities, good functional group tolerance, and substrate scope including diverse bioactive compounds and drug-like molecules. Mechanistic studies indicate that the Lewis acid additive is the key to realizing the efficient umpolung addition of nucleophilic aminyl radicals to electron-rich alkenes, which represents an elegant activation strategy for aminyl radicals."],"journal":["Journal of the American Chemical Society"],"pagination":["6464-6471"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11869293"],"repository":["biostudies-literature"],"pubmed_title":["Copper-Catalyzed Selective Amino-alkoxycarbonylation of Unactivated Alkenes with CO."],"pmcid":["PMC11869293"],"pubmed_authors":["Yan SS","Beller M","Jackstell R"],"additional_accession":[]},"is_claimable":false,"name":"Copper-Catalyzed Selective Amino-alkoxycarbonylation of Unactivated Alkenes with CO.","description":"1,2-Amino-difunctionalization reactions of alkenes allow the efficient introduction of different functional groups and the rapid construction of valuable functionalized amines. In this respect, we report a copper-catalyzed 1,2-amino-alkoxycarbonylation of unactivated alkenes with CO and alkylamine precursors in the presence of a Lewis acid additive. The novel protocol allows direct access to valuable β-amino acid derivatives from easily available starting materials. The presented methods feature high chemo- and regioselectivities, good functional group tolerance, and substrate scope including diverse bioactive compounds and drug-like molecules. Mechanistic studies indicate that the Lewis acid additive is the key to realizing the efficient umpolung addition of nucleophilic aminyl radicals to electron-rich alkenes, which represents an elegant activation strategy for aminyl radicals.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-22T20:04:49.055Z","creation":"2025-04-06T03:03:58.708Z"},"accession":"S-EPMC11869293","cross_references":{"pubmed":["39961097"],"doi":["10.1021/jacs.4c13723"]}}