biostudies-literatureFlouri DNICHD NIH HHSUKRI | Engineering and Physical Sciences Research Council (EPSRC)Medical Research CouncilAustralian Research CouncilH2020 Marie Sklodowska-Curie Actions (MCSA)|HORIZON-TMA-MSCA-2022-PF-EFBiotechnology and Biological Sciences Research Council1029-1044https://www.ebi.ac.uk/biostudies/studies/S-EPMC11870080biostudies-literatureUnknown603(5)An adequate supply of oxygen is crucial for optimal fetal growth and development. Estimation of quantitative indices that reflect tissue diffusivity and oxygenation have been enabled by advances in magnetic resonance imaging (MRI) technology. However, the current diagnostic tools in clinical obstetrics, such as Doppler ultrasound measurements of umbilical blood flow and cardiotocography, do not offer direct information about the oxygen supply to the fetus, nor placental function in vivo. Although MRI provides an opportunity to identify critical changes in fetal oxygenation, exact tissue oxygen content cannot be established in humans. Preclinical models such as pregnant sheep allow the use of invasive methods to validate MRI measurements. The present study investigates the relationship betwThe Journal of physiologyFeasibility of multimodal magnetic resonance imaging to assess maternal hyperoxygenation in sheep pregnancy.PMC11870080DP220103289NS/A000027/1R01 HD108833BB/Y514214/1MR/X010007/1DP190102263101108945-InSilicoPlacentaDarby JRTFlouri DHolman SLWilliams GDavid ALMorrison JLMelbourne AVavourakis VfalseFeasibility of multimodal magnetic resonance imaging to assess maternal hyperoxygenation in sheep pregnancy.An adequate supply of oxygen is crucial for optimal fetal growth and development. Estimation of quantitative indices that reflect tissue diffusivity and oxygenation have been enabled by advances in magnetic resonance imaging (MRI) technology. However, the current diagnostic tools in clinical obstetrics, such as Doppler ultrasound measurements of umbilical blood flow and cardiotocography, do not offer direct information about the oxygen supply to the fetus, nor placental function in vivo. Although MRI provides an opportunity to identify critical changes in fetal oxygenation, exact tissue oxygen content cannot be established in humans. Preclinical models such as pregnant sheep allow the use of invasive methods to validate MRI measurements. The present study investigates the relationship betw2025-01-01T00:00:00Z2025 Mar2025-04-04T01:12:00.884Z2025-04-04T01:12:00.884ZS-EPMC118700803993783410.1113/JP287272