biostudies-literatureFigueiredo NCNIGMS NIH HHSe0318436https://www.ebi.ac.uk/biostudies/studies/S-EPMC11870366biostudies-literatureUnknown20(2)The kallikrein-kinin system (KKS) is a complex enzymatic system involved in multiple biological processes, particularly inflammation. The system's peptides exert broad effects through two receptors, B1 (B1R) and B2 (B2R), expressed in various cell types, including osteoblasts. However, the impact of this system on bone remodeling induced by mechanical force needs to be better understood. This study aimed to elucidate the role of the B2 kinin receptor in bone phenotype and remodeling under mechanical stress. Orthodontic forces were applied to the upper first molars of B2R-/- mice and wild-type controls. Bone parameters, bone cellular counts, expression of inflammatory biomarkers, and osteoblast and osteoclast differentiation and activity were assessed using microtomography, histological anaPloS oneDeletion of kinin receptor B2 enhances orthodontic tooth movement and alveolar bone remodeling.PMC11870366P20 GM103499Pandruvada SPiacsek MTeixeira MMFigueiredo NCSilva TAMontalvany-Antonucci CCSantos MSAmaral FAAndrade IMacari SfalseDeletion of kinin receptor B2 enhances orthodontic tooth movement and alveolar bone remodeling.The kallikrein-kinin system (KKS) is a complex enzymatic system involved in multiple biological processes, particularly inflammation. The system's peptides exert broad effects through two receptors, B1 (B1R) and B2 (B2R), expressed in various cell types, including osteoblasts. However, the impact of this system on bone remodeling induced by mechanical force needs to be better understood. This study aimed to elucidate the role of the B2 kinin receptor in bone phenotype and remodeling under mechanical stress. Orthodontic forces were applied to the upper first molars of B2R-/- mice and wild-type controls. Bone parameters, bone cellular counts, expression of inflammatory biomarkers, and osteoblast and osteoclast differentiation and activity were assessed using microtomography, histological ana2025-01-01T00:00:00Z20252025-04-22T18:51:54.251Z2025-04-06T02:38:40.15ZS-EPMC118703664001993110.1371/journal.pone.0318436