{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ou S"],"funding":["Natural Science Funding of Guangdong Province","National Natural Science Foundation of China"],"pagination":["599-609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11871191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(2)"],"pubmed_abstract":["<h4>Purpose</h4>To elucidatethe epigenetic alteration associated with impaired oogenesis in endometrioma using multi-omic approaches.<h4>Methods</h4>ATAC-seq was performed on the granulosa cells (GCs) of 6 patients (3 with endometrioma and 3 without). Follicular samples from another 20 patients (10 with endometrioma and 10 without) were collected for mRNA-seq analysis of GCs and extracellular vesicles (EVs) of follicular fluid. qRT-PCR validated candidate genes in GCs from 44 newly enrolled patients (19 with endometrioma and 25 without). mRNA abundance was compared with the Mann-Whitney test. Pearson's correlation analyzed relationships between candidate genes and oocyte parameters.<h4>Results</h4>Chromatin accessibility and gene expression profiles of GCs from endometrioma patients differ"],"journal":["Journal of assisted reproduction and genetics"],"pubmed_title":["Comparison of chromatin accessibility remodeling of granulosa cells in patients with endometrioma or pelvic/tubal infertility."],"pmcid":["PMC11871191"],"funding_grant_id":["32170612","4210015092","2017A030313895","82171642","81671523"],"pubmed_authors":["Li Y","Huang J","Pan P","Cao C","Wang W","Li R","Ou S","Sun X","Jiao X","Zhang Q","Wei L"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of chromatin accessibility remodeling of granulosa cells in patients with endometrioma or pelvic/tubal infertility.","description":"<h4>Purpose</h4>To elucidatethe epigenetic alteration associated with impaired oogenesis in endometrioma using multi-omic approaches.<h4>Methods</h4>ATAC-seq was performed on the granulosa cells (GCs) of 6 patients (3 with endometrioma and 3 without). Follicular samples from another 20 patients (10 with endometrioma and 10 without) were collected for mRNA-seq analysis of GCs and extracellular vesicles (EVs) of follicular fluid. qRT-PCR validated candidate genes in GCs from 44 newly enrolled patients (19 with endometrioma and 25 without). mRNA abundance was compared with the Mann-Whitney test. Pearson's correlation analyzed relationships between candidate genes and oocyte parameters.<h4>Results</h4>Chromatin accessibility and gene expression profiles of GCs from endometrioma patients differ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-15T06:27:57.161Z","creation":"2026-06-15T03:08:44.622Z"},"accession":"S-EPMC11871191","cross_references":{"pubmed":["39485574"],"doi":["10.1007/s10815-024-03302-7"]}}