{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou W"],"funding":["NIEHS NIH HHS"],"pagination":["152176"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11871371"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["809"],"pubmed_abstract":["We previously showed the development of cardiac remodeling (hypertrophy or fibrosis) in mice with either post-weaning high-fat diet (HFD, 60% kcal fat) feeding or exposure to chronic low-dose cadmium. Here, we determined whether whole-life exposure to environmentally relevant, low-dose cadmium affects the susceptibility of offspring to post-weaning HFD-induced cardiac pathologies and function. Besides, we also determined whether these effects are sex-dependent. Male and female mice were exposed to cadmium-containing (0, 0.5, or 5 parts per million [ppm]) drinking water before breeding; the pregnant mice and dams with offspring continually drank the same cadmium-containing water. After weaning, the offspring were continued on the same regime as their parents and fed either a HFD or normal f"],"journal":["The Science of the total environment"],"pubmed_title":["Sex differences in the effects of whole-life, low-dose cadmium exposure on postweaning high-fat diet-induced cardiac pathogeneses."],"pmcid":["PMC11871371"],"funding_grant_id":["T32 ES011564","P30 ES030283"],"pubmed_authors":["Men H","Lin Q","Zheng Y","Zhang H","Tan Y","Zhou W","Young JL","Cai L","Xu H","Yu H","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"Sex differences in the effects of whole-life, low-dose cadmium exposure on postweaning high-fat diet-induced cardiac pathogeneses.","description":"We previously showed the development of cardiac remodeling (hypertrophy or fibrosis) in mice with either post-weaning high-fat diet (HFD, 60% kcal fat) feeding or exposure to chronic low-dose cadmium. Here, we determined whether whole-life exposure to environmentally relevant, low-dose cadmium affects the susceptibility of offspring to post-weaning HFD-induced cardiac pathologies and function. Besides, we also determined whether these effects are sex-dependent. Male and female mice were exposed to cadmium-containing (0, 0.5, or 5 parts per million [ppm]) drinking water before breeding; the pregnant mice and dams with offspring continually drank the same cadmium-containing water. After weaning, the offspring were continued on the same regime as their parents and fed either a HFD or normal f","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T01:11:53.935Z","creation":"2025-04-04T01:11:53.935Z"},"accession":"S-EPMC11871371","cross_references":{"pubmed":["34875320"],"doi":["10.1016/j.scitotenv.2021.152176"]}}