{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Goswami D"],"pubmed_abstract":["The rise of methicillin-resistant Staphylococcus aureus (MRSA) as a major public health threat underscores a critical need for new antibacterial strategies. Quercetin is a naturally occurring flavonoid with a range of bioactivities, including antibacterial activity against S. aureus. However, how quercetin inhibits S. aureus and binds to its potential molecular target is not well understood. Understanding the interaction of quercetin with potential bacterial targets may provide crucial insights for developing modified derivatives with better drug-like properties. To investigate potential targets of quercetin in S. aureus, we employed a targeted subtractive proteomics approach, which identified the glycosyltransferase MurG as a novel quercetin target. Through rigorous molecular docking and "],"journal":["Scientific reports"],"pagination":["7309"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11873250"],"repository":["biostudies-literature"],"pubmed_title":["MurG as a potential target of quercetin in Staphylococcus aureus supported by evidence from subtractive proteomics and molecular dynamics."],"pmcid":["PMC11873250"],"pubmed_authors":["Dabhi M","Sharkey LKR","Goswami D","Pidot SJ","Prajapati J"],"additional_accession":[]},"is_claimable":false,"name":"MurG as a potential target of quercetin in Staphylococcus aureus supported by evidence from subtractive proteomics and molecular dynamics.","description":"The rise of methicillin-resistant Staphylococcus aureus (MRSA) as a major public health threat underscores a critical need for new antibacterial strategies. Quercetin is a naturally occurring flavonoid with a range of bioactivities, including antibacterial activity against S. aureus. However, how quercetin inhibits S. aureus and binds to its potential molecular target is not well understood. Understanding the interaction of quercetin with potential bacterial targets may provide crucial insights for developing modified derivatives with better drug-like properties. To investigate potential targets of quercetin in S. aureus, we employed a targeted subtractive proteomics approach, which identified the glycosyltransferase MurG as a novel quercetin target. Through rigorous molecular docking and ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-02T18:13:55.191Z","creation":"2025-04-07T11:27:18.565Z"},"accession":"S-EPMC11873250","cross_references":{"pubmed":["40025069"],"doi":["10.1038/s41598-025-90395-4"]}}