{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(2)"],"submitter":["de Nes LCF"],"pubmed_abstract":["<h4>Aim</h4>Locally advanced colon cancer (LACC) often necessitates complex prognosis-determining treatment. This study investigated the impact of hospital volume on short- and long-term outcomes following surgery for LACC.<h4>Method</h4>Data involving all patients with LACC categorized as clinical T4 and/or N2, between 2015 and 2019 in the Netherlands, were extracted from the Netherlands Cancer Registry. Hospitals were stratified into low volume (1-19 LACC resections per year), medium volume (20-29 LACC resections per year) and high volume (≥30 LACC resections per year). Data were analysed using Kaplan-Meier curves, logistic regression analysis and Cox-regression models.<h4>Results</h4>A total of 49 298 patients were diagnosed with colon cancer, of whom 9206 (18.7%) had locally advanced disease. Of these 9206 patients, resection was performed in 8537 with a median age of 71 (interquartile range: 63-78) years. Patients were more likely to undergo laparoscopic procedures in high-volume hospitals than in low-volume hospitals (OR = 1.28, 95% CI: 1.12-1.46). No risk differences in anastomotic leakage or postoperative 90-day mortality were observed according to hospital volume. Five-year overall survival rates were comparable among high-, medium- and low-volume hospitals (58.7% vs. 58.0% vs. 60.0%, p = 0.62). Hospital volume was not associated with overall survival in multivariable analysis. Independent predictors of worse overall survival included older age, higher American Society of Anaesthesiologists score, emergency/urgent setting, anastomotic leakage, higher pTNM status, involved resection margins and no adjuvant chemotherapy.<h4>Conclusion</h4>Despite the complexity of surgical treatment, hospital volume was not associated with survival in LACC. Hospital volume might be an imperfect surrogate for quality assessment."],"journal":["Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland"],"pagination":["e17288"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11873530"],"repository":["biostudies-literature"],"pubmed_title":["Impact of hospital volume on survival in patients with locally advanced colon cancer - A Dutch population-based study."],"pmcid":["PMC11873530"],"pubmed_authors":["de Nes LCF","Vissers PAJ","Verhoeven RH","de Wilt JHW","Tanis PJ"],"additional_accession":[]},"is_claimable":false,"name":"Impact of hospital volume on survival in patients with locally advanced colon cancer - A Dutch population-based study.","description":"<h4>Aim</h4>Locally advanced colon cancer (LACC) often necessitates complex prognosis-determining treatment. This study investigated the impact of hospital volume on short- and long-term outcomes following surgery for LACC.<h4>Method</h4>Data involving all patients with LACC categorized as clinical T4 and/or N2, between 2015 and 2019 in the Netherlands, were extracted from the Netherlands Cancer Registry. Hospitals were stratified into low volume (1-19 LACC resections per year), medium volume (20-29 LACC resections per year) and high volume (≥30 LACC resections per year). Data were analysed using Kaplan-Meier curves, logistic regression analysis and Cox-regression models.<h4>Results</h4>A total of 49 298 patients were diagnosed with colon cancer, of whom 9206 (18.7%) had locally advanced disease. Of these 9206 patients, resection was performed in 8537 with a median age of 71 (interquartile range: 63-78) years. Patients were more likely to undergo laparoscopic procedures in high-volume hospitals than in low-volume hospitals (OR = 1.28, 95% CI: 1.12-1.46). No risk differences in anastomotic leakage or postoperative 90-day mortality were observed according to hospital volume. Five-year overall survival rates were comparable among high-, medium- and low-volume hospitals (58.7% vs. 58.0% vs. 60.0%, p = 0.62). Hospital volume was not associated with overall survival in multivariable analysis. Independent predictors of worse overall survival included older age, higher American Society of Anaesthesiologists score, emergency/urgent setting, anastomotic leakage, higher pTNM status, involved resection margins and no adjuvant chemotherapy.<h4>Conclusion</h4>Despite the complexity of surgical treatment, hospital volume was not associated with survival in LACC. Hospital volume might be an imperfect surrogate for quality assessment.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-03T23:44:16.349Z","creation":"2025-04-03T23:44:16.349Z"},"accession":"S-EPMC11873530","cross_references":{"pubmed":["39865913"],"doi":["10.1111/codi.17288"]}}