biostudies-literatureUnknown25(1)de Jong GM<h4>Background</h4>Outbreaks of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) have been documented at multiple sites worldwide. Several studies have reported an elevated infection rate of CA-MRSA infections in men having sex with men (MSM), suggesting CA-MRSA can behave as a sexually transmitted infection (STI). To assess the potential public health impact of CA-MRSA transmission amongst MSM, a systematic review of the literature was conducted to identify risk factors and prevalence of CA-MRSA colonization and infection in MSM.<h4>Methods</h4>The electronic database Embase.com (containing Embase and Medline) was systematically searched to identify studies investigating CA-MRSA colonization and infection from inception up to 19 January 2024. Two independent reviewBMC infectious diseases299https://www.ebi.ac.uk/biostudies/studies/S-EPMC11874445biostudies-literatureMethicillin-resistant Staphylococcus aureus (MRSA) in men having sex with men (MSM): a systematic review.PMC11874445Hoornenborg Ede Jong GMde Stoppelaar SFvan der Boor SCJoosten REBos HNotermans DWvan Bokhoven CfalseMethicillin-resistant Staphylococcus aureus (MRSA) in men having sex with men (MSM): a systematic review.<h4>Background</h4>Outbreaks of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) have been documented at multiple sites worldwide. Several studies have reported an elevated infection rate of CA-MRSA infections in men having sex with men (MSM), suggesting CA-MRSA can behave as a sexually transmitted infection (STI). To assess the potential public health impact of CA-MRSA transmission amongst MSM, a systematic review of the literature was conducted to identify risk factors and prevalence of CA-MRSA colonization and infection in MSM.<h4>Methods</h4>The electronic database Embase.com (containing Embase and Medline) was systematically searched to identify studies investigating CA-MRSA colonization and infection from inception up to 19 January 2024. Two independent review2025-01-01T00:00:00Z2025 Mar2025-04-03T23:36:43.938Z2025-04-03T23:36:43.938ZS-EPMC118744454002542310.1186/s12879-025-10593-3