{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yi J"],"funding":["Ministry of Science and Technology of the People's Republic of China (MOST)","MOST | National Natural Science Foundation of China (NSFC)"],"pagination":["e2420383122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11874584"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(8)"],"pubmed_abstract":["The molecular mechanisms underlying estrogen receptor (ER)-positive breast carcinogenesis and drug resistance remain incompletely understood. Elevated expression of CCND1 is linked to enhanced invasiveness, poorer prognosis, and resistance to drug therapies in ER-positive breast cancer. In this study, we identify a highly expressed circular RNA (circRNA) derived from <i>FOXK2</i>, called circFOXK2, which plays a key role in stabilizing <i>CCND1</i> mRNA, thereby promoting cell cycle progression, cell growth, and endocrine therapy resistance in ER-positive breast cancer cells. Mechanistically, circFOXK2 binds directly to <i>CCND1</i> mRNA via RNA-RNA pairing and recruits the RNA-binding protein ELAVL1/HuR, stabilizing the <i>CCND1</i> mRNA and enhancing CCND1 protein levels. This results in"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer."],"pmcid":["PMC11874584"],"funding_grant_id":["U22A20320","82273236","2020YFA0803600","2023YFA0915602","82125028","2020YFA0112300","31871319","91953114"],"pubmed_authors":["Yi J","Zhang YY","Hu GS","Nie RC","He H","Luo DX","Du J","Chen X","Chen S","Wen XS","Wang L","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer.","description":"The molecular mechanisms underlying estrogen receptor (ER)-positive breast carcinogenesis and drug resistance remain incompletely understood. Elevated expression of CCND1 is linked to enhanced invasiveness, poorer prognosis, and resistance to drug therapies in ER-positive breast cancer. In this study, we identify a highly expressed circular RNA (circRNA) derived from <i>FOXK2</i>, called circFOXK2, which plays a key role in stabilizing <i>CCND1</i> mRNA, thereby promoting cell cycle progression, cell growth, and endocrine therapy resistance in ER-positive breast cancer cells. Mechanistically, circFOXK2 binds directly to <i>CCND1</i> mRNA via RNA-RNA pairing and recruits the RNA-binding protein ELAVL1/HuR, stabilizing the <i>CCND1</i> mRNA and enhancing CCND1 protein levels. This results in","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-07-10T03:08:21.818Z","creation":"2025-07-10T03:08:21.818Z"},"accession":"S-EPMC11874584","cross_references":{"pubmed":["40233410"],"doi":["10.1073/pnas.2420383122"]}}