{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(1)"],"submitter":["Iida K"],"pubmed_abstract":["<h4>Background</h4>The SARS-CoV-2 pandemic provided important insights into the relationship between infectious diseases and the human genome. A genomic region encoding the 2'-5'-oligoadenylate synthetase (OAS) family proteins that sense viral genomic RNAs and trigger an antiviral response contains single nucleotide polymorphisms (SNPs) associated with SARS-CoV-2 infection susceptibility. A high-risk SNP identified at the splice acceptor site of OAS1 exon 6-a terminal exon-alters the proportion of various splicing isoforms of OAS1 and its activity. However, the actual causality of this SNP or splicing to infection susceptibility remains unknown.<h4>Results</h4>In this study, it was found that serine-arginine-rich splicing factor 6 (SRSF6) binds to the splice donor site of the human OAS1 ex"],"journal":["BMC biology"],"pagination":["60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11874701"],"repository":["biostudies-literature"],"pubmed_title":["Switching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection."],"pmcid":["PMC11874701"],"pubmed_authors":["Iida K","Kurosawa R","Denawa M","Noda T","Ajiro M","Hagiwara M","Nakano-Kobayashi A","Takenaga T","Muramoto Y"],"additional_accession":[]},"is_claimable":false,"name":"Switching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection.","description":"<h4>Background</h4>The SARS-CoV-2 pandemic provided important insights into the relationship between infectious diseases and the human genome. A genomic region encoding the 2'-5'-oligoadenylate synthetase (OAS) family proteins that sense viral genomic RNAs and trigger an antiviral response contains single nucleotide polymorphisms (SNPs) associated with SARS-CoV-2 infection susceptibility. A high-risk SNP identified at the splice acceptor site of OAS1 exon 6-a terminal exon-alters the proportion of various splicing isoforms of OAS1 and its activity. However, the actual causality of this SNP or splicing to infection susceptibility remains unknown.<h4>Results</h4>In this study, it was found that serine-arginine-rich splicing factor 6 (SRSF6) binds to the splice donor site of the human OAS1 ex","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-01T23:10:25.393Z","creation":"2025-04-04T02:11:18.956Z"},"accession":"S-EPMC11874701","cross_references":{"pubmed":["40025489"],"doi":["10.1186/s12915-025-02173-3"]}}