biostudies-literatureUnknown23(1)Iida K<h4>Background</h4>The SARS-CoV-2 pandemic provided important insights into the relationship between infectious diseases and the human genome. A genomic region encoding the 2'-5'-oligoadenylate synthetase (OAS) family proteins that sense viral genomic RNAs and trigger an antiviral response contains single nucleotide polymorphisms (SNPs) associated with SARS-CoV-2 infection susceptibility. A high-risk SNP identified at the splice acceptor site of OAS1 exon 6-a terminal exon-alters the proportion of various splicing isoforms of OAS1 and its activity. However, the actual causality of this SNP or splicing to infection susceptibility remains unknown.<h4>Results</h4>In this study, it was found that serine-arginine-rich splicing factor 6 (SRSF6) binds to the splice donor site of the human OAS1 exBMC biology60https://www.ebi.ac.uk/biostudies/studies/S-EPMC11874701biostudies-literatureSwitching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection.PMC11874701Iida KKurosawa RDenawa MNoda TAjiro MHagiwara MNakano-Kobayashi ATakenaga TMuramoto YfalseSwitching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection.<h4>Background</h4>The SARS-CoV-2 pandemic provided important insights into the relationship between infectious diseases and the human genome. A genomic region encoding the 2'-5'-oligoadenylate synthetase (OAS) family proteins that sense viral genomic RNAs and trigger an antiviral response contains single nucleotide polymorphisms (SNPs) associated with SARS-CoV-2 infection susceptibility. A high-risk SNP identified at the splice acceptor site of OAS1 exon 6-a terminal exon-alters the proportion of various splicing isoforms of OAS1 and its activity. However, the actual causality of this SNP or splicing to infection susceptibility remains unknown.<h4>Results</h4>In this study, it was found that serine-arginine-rich splicing factor 6 (SRSF6) binds to the splice donor site of the human OAS1 ex2025-01-01T00:00:00Z2025 Mar2026-06-01T23:10:25.393Z2025-04-04T02:11:18.956ZS-EPMC118747014002548910.1186/s12915-025-02173-3