biostudies-literatureUnknown10(3)GBD Epilepsy Collaborators<h4>Background</h4>Epilepsy is one of the most common serious neurological disorders and affects individuals of all ages across the globe. The aim of this study is to provide estimates of the epilepsy burden on the global, regional, and national levels for 1990-2021.<h4>Methods</h4>Using well established Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) methodology, we quantified the prevalence of active idiopathic (epilepsy of genetic or unknown origin) and secondary epilepsy (epilepsy due to an underlying abnormality of the brain structure or chemistry), as well as incidence, death, and disability-adjusted life-years (DALYs) by age, sex, and location (globally, 21 GBD regions and seven super-regions, World Bank country income levels, Socio-demographic Index [SDI], and 204The Lancet. Public healthe203-e227https://www.ebi.ac.uk/biostudies/studies/S-EPMC11876103biostudies-literatureGlobal, regional, and national burden of epilepsy, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.PMC11876103Girmay AARedwan EMMMDhane ASFazeli PAbu Rumeileh SPazoki Toroudi HPoddighe DMokdad AHMoodi Ghalibaf ABakkannavar SMKhormali MTemsah RMHFoschi MRout HSShamsutdinova AHwang BFMulita FSarode SCAbualruz HJalilzadeh Yengejeh RDohare SMunkhsaikhan YNzoputam OJFagbamigbe AFHegazi OETsermpini EEUrso DVarma RPAl Omari ORashidi MMBandyopadhyay SKashoo FZMisra AKRoot KTKhalilian AKabir ZSaddik BALahariya CMeretoja AAddo IYAl-Fatly BKimokoti RWSaad AMABardhan MGouravani MDsouza HLBhaskar SHosseinzadeh MQasim NHDadras OVinayak MEkholuenetale MKaur HKrishnamoorthy VYu CRajabpour Sanati ASabet CJDandona RRodriguez JABPanda SKPensato USuresh VEissazade NPadubidri JRTemsah MHBejarano Ramirez DFJacob LPham HNHasani HSharma AZyoud SHJamora RDGHassan ASolanki SGebregergis 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Awaidy SBeyene KAJoseph NPribadi DRAVinueza Veloz AFMajeed AAnyasodor AERathish DSharifan ALam JSendekie AKKundu SfalseGlobal, regional, and national burden of epilepsy, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.<h4>Background</h4>Epilepsy is one of the most common serious neurological disorders and affects individuals of all ages across the globe. The aim of this study is to provide estimates of the epilepsy burden on the global, regional, and national levels for 1990-2021.<h4>Methods</h4>Using well established Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) methodology, we quantified the prevalence of active idiopathic (epilepsy of genetic or unknown origin) and secondary epilepsy (epilepsy due to an underlying abnormality of the brain structure or chemistry), as well as incidence, death, and disability-adjusted life-years (DALYs) by age, sex, and location (globally, 21 GBD regions and seven super-regions, World Bank country income levels, Socio-demographic Index [SDI], and 2042025-01-01T00:00:00Z2025 Mar2025-04-04T00:48:56.26Z2025-04-04T00:48:56.26ZS-EPMC118761034001529110.1016/S2468-2667(24)00302-5