{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kawai H"],"funding":["Japan Society for the Promotion of Science"],"pagination":["343-354"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11876232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["486(2)"],"pubmed_abstract":["<h4>Introduction</h4>HNF4α expression and SMARCA4 loss were thought to be features of non-terminal respiratory unit (TRU)-type lung adenocarcinomas, but their relationships remained unclear.<h4>Materials and methods</h4>HNF4α-positive cases among 241 lung adenocarcinomas were stratified based on TTF-1 and SMARCA4 expressions, histological subtypes, and driver mutations. Immunohistochemical analysis was performed using xenograft tumors of lung adenocarcinoma cell lines with high HNF4A expression.<h4>Result</h4>HNF4α-positive adenocarcinomas(n = 33) were divided into two groups: the variant group(15 mucinous, 2 enteric, and 1 colloid), where SMARCA4 was retained in all cases, and the conventional non-mucinous group(6 papillary, 5 solid, and 4 acinar), where SMARCA4 was lost in 3/15 cases(20%"],"journal":["Virchows Archiv : an international journal of pathology"],"pubmed_title":["Expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinomas: impacts on clinicopathological and genetic features."],"pmcid":["PMC11876232"],"funding_grant_id":["22H02840","19K07441","23K14469","18H02634","23K06470","17K15652"],"pubmed_authors":["Ishikawa S","Kawai H","Hagiwara K","Shiba-Ishii A","Kawamatsu N","Fujita K","Kihara A","Miura T","Amano Y","Matsubara D","Fukayama M","Shibano T","Tsubochi H","Nakagawa T","Yoshimoto T","Endo S","Sakuma Y","Niki T","Ushiku T"],"additional_accession":[]},"is_claimable":false,"name":"Expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinomas: impacts on clinicopathological and genetic features.","description":"<h4>Introduction</h4>HNF4α expression and SMARCA4 loss were thought to be features of non-terminal respiratory unit (TRU)-type lung adenocarcinomas, but their relationships remained unclear.<h4>Materials and methods</h4>HNF4α-positive cases among 241 lung adenocarcinomas were stratified based on TTF-1 and SMARCA4 expressions, histological subtypes, and driver mutations. Immunohistochemical analysis was performed using xenograft tumors of lung adenocarcinoma cell lines with high HNF4A expression.<h4>Result</h4>HNF4α-positive adenocarcinomas(n = 33) were divided into two groups: the variant group(15 mucinous, 2 enteric, and 1 colloid), where SMARCA4 was retained in all cases, and the conventional non-mucinous group(6 papillary, 5 solid, and 4 acinar), where SMARCA4 was lost in 3/15 cases(20%","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T09:10:07.179Z","creation":"2025-04-04T09:10:07.179Z"},"accession":"S-EPMC11876232","cross_references":{"pubmed":["38710944"],"doi":["10.1007/s00428-024-03816-6"]}}