{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["48(3)"],"submitter":["Verrienti A"],"funding":["Università degli Studi di Roma La Sapienza"],"pubmed_abstract":["<h4>Purpose</h4>Papillary thyroid carcinoma (PTC) is the most common malignant thyroid neoplasm, accounting for approximately 85% of all follicular cell-derived thyroid nodules. This study aimed to assess the diagnostic potential of circulating microRNA-146a-5p and microRNA-221-3p as biomarkers for PTC and their usefulness in monitoring disease progression during patient follow-up.<h4>Methods</h4>An observational study was conducted on two cohorts of PTC patients and healthy controls (HCs) using digital PCR. We collected patients' clinical, biochemical, and imaging data during the post-surgery surveillance. We analyzed the levels of circulating miRNAs in serum samples of patients before surgery and during the follow-up, including those with indeterminate/biochemical incomplete response (In"],"journal":["Journal of endocrinological investigation"],"pagination":["619-631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11876262"],"repository":["biostudies-literature"],"pubmed_title":["Serum microRNA-146a-5p and microRNA-221-3p as potential clinical biomarkers for papillary thyroid carcinoma."],"pmcid":["PMC11876262"],"pubmed_authors":["Verrienti A","Di Gioia C","Sponziello M","Del Gatto V","Maranghi M","Grani G","Filetti S","Durante C","Giacomelli L","Biffoni M","Pecce V","Barp S"],"additional_accession":[]},"is_claimable":false,"name":"Serum microRNA-146a-5p and microRNA-221-3p as potential clinical biomarkers for papillary thyroid carcinoma.","description":"<h4>Purpose</h4>Papillary thyroid carcinoma (PTC) is the most common malignant thyroid neoplasm, accounting for approximately 85% of all follicular cell-derived thyroid nodules. This study aimed to assess the diagnostic potential of circulating microRNA-146a-5p and microRNA-221-3p as biomarkers for PTC and their usefulness in monitoring disease progression during patient follow-up.<h4>Methods</h4>An observational study was conducted on two cohorts of PTC patients and healthy controls (HCs) using digital PCR. We collected patients' clinical, biochemical, and imaging data during the post-surgery surveillance. We analyzed the levels of circulating miRNAs in serum samples of patients before surgery and during the follow-up, including those with indeterminate/biochemical incomplete response (In","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T01:12:13.383Z","creation":"2025-04-04T01:12:13.383Z"},"accession":"S-EPMC11876262","cross_references":{"pubmed":["39298113"],"doi":["10.1007/s40618-024-02467-3"]}}