biostudies-literatureUnknown2025Wu C<b>Introduction:</b> We conducted a systematic review and meta-analysis to evaluate the effects of the 5:2 diet on weight loss and cardiovascular disease (CVD) risk factors in overweight and obese individuals. <b>Methods:</b> Databases (PubMed, The Cochrane Library, Web of Science, Embase) were searched for randomized controlled trials of the intervention effects of the 5:2 diet in overweight and obese individuals. The search period was from database establishment to April 2024. RevMan 5.3 and Stata 14.0 were used for the meta-analysis. <b>Results:</b> A total of 20 articles with 1393 participants were finally included. There were 689 participants in the treatment groups and 704 in the control groups. The meta-analysis showed that the 5:2 diet significantly reduces body weight, body mass iInternational journal of endocrinology6658512https://www.ebi.ac.uk/biostudies/studies/S-EPMC11876533biostudies-literatureEffect of the 5:2 Diet on Weight Loss and Cardiovascular Disease Risk Factors in Overweight and/or Obesity: A Systematic Review and Meta-Analysis.PMC11876533Piao CWu CYu JChen BZhang QfalseEffect of the 5:2 Diet on Weight Loss and Cardiovascular Disease Risk Factors in Overweight and/or Obesity: A Systematic Review and Meta-Analysis.<b>Introduction:</b> We conducted a systematic review and meta-analysis to evaluate the effects of the 5:2 diet on weight loss and cardiovascular disease (CVD) risk factors in overweight and obese individuals. <b>Methods:</b> Databases (PubMed, The Cochrane Library, Web of Science, Embase) were searched for randomized controlled trials of the intervention effects of the 5:2 diet in overweight and obese individuals. The search period was from database establishment to April 2024. RevMan 5.3 and Stata 14.0 were used for the meta-analysis. <b>Results:</b> A total of 20 articles with 1393 participants were finally included. There were 689 participants in the treatment groups and 704 in the control groups. The meta-analysis showed that the 5:2 diet significantly reduces body weight, body mass i2025-01-01T00:00:00Z20252025-04-18T12:47:04.919Z2025-04-06T22:07:46.68ZS-EPMC118765334004176110.1155/ije/6658512