biostudies-literatureUnknown81Wang JC<h4>Background</h4>With life expectancy for people living with HIV (PLWH) approaching that of the general population, age-related conditions like osteoporosis are increasingly common. Both HIV infection and long-term antiretroviral therapy (ART), particularly tenofovir disoproxil fumarate (TDF), are associated with early-onset osteoporosis. Bisphosphonates are commonly used for treatment, but the optimal strategy for improving bone health in PLWH remains unclear.<h4>Methods</h4>We conducted a network meta-analysis (NMA) with component analysis of randomized controlled trials (RCTs) identified from Medline, EMBASE, Cochrane CENTRAL, Scopus, Web of Science and CINAHL EBSCO databases, from inception to December 1, 2024. The study included RCTs comparing zoledronate, alendronate, calcium and vEClinicalMedicine103103https://www.ebi.ac.uk/biostudies/studies/S-EPMC11876934biostudies-literatureOptimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials.PMC11876934Chang YFTu YKFang CJKuan FCLai PCLi CWChung SMHsu KLChen PLWang JCWu CHWu PTTai TWShih CAfalseOptimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials.<h4>Background</h4>With life expectancy for people living with HIV (PLWH) approaching that of the general population, age-related conditions like osteoporosis are increasingly common. Both HIV infection and long-term antiretroviral therapy (ART), particularly tenofovir disoproxil fumarate (TDF), are associated with early-onset osteoporosis. Bisphosphonates are commonly used for treatment, but the optimal strategy for improving bone health in PLWH remains unclear.<h4>Methods</h4>We conducted a network meta-analysis (NMA) with component analysis of randomized controlled trials (RCTs) identified from Medline, EMBASE, Cochrane CENTRAL, Scopus, Web of Science and CINAHL EBSCO databases, from inception to December 1, 2024. The study included RCTs comparing zoledronate, alendronate, calcium and v2025-01-01T00:00:00Z2025 Mar2025-04-04T19:26:58.052Z2025-04-04T19:26:58.052ZS-EPMC118769344004086210.1016/j.eclinm.2025.103103