biostudies-literatureUnknown9(2)Hanai Y<h4>Background</h4>Appropriate antibiotic prophylaxis is essential for preventing surgical site infections (SSI); however, the clinical benefit of intraoperative redosing remains unclear and controversial owing to insufficient reliable evidence. Therefore, we performed a systematic review and meta-analysis to assess the effectiveness of prophylactic antibiotic redosing in lengthy surgical procedures.<h4>Methods</h4>We systematically searched the PubMed, Cochrane Library, Web of Science, and Ichushi-Web databases for articles published until 31 December, 2023. We compared the incidence of SSI between patients receiving and not receiving intraoperative redosing of antibiotics in surgeries lasting ≥3 h. Subgroup analyses were conducted across study characteristics. Odds ratios (ORs) and 95% cAnnals of gastroenterological surgery369-378https://www.ebi.ac.uk/biostudies/studies/S-EPMC11877348biostudies-literatureIntraoperative redosing of antibiotics for prevention of surgical site infections: A systematic review and meta-analysis.PMC11877348Yoshida MHirai JKitagawa YYamashita COhge HShinkawa HSuzuki KKobayashi MMatsuo KShimizu JMohri YHaji SMizuguchi TKouzu KHanai YMayumi TNobuhara HShinji SUchino MfalseIntraoperative redosing of antibiotics for prevention of surgical site infections: A systematic review and meta-analysis.<h4>Background</h4>Appropriate antibiotic prophylaxis is essential for preventing surgical site infections (SSI); however, the clinical benefit of intraoperative redosing remains unclear and controversial owing to insufficient reliable evidence. Therefore, we performed a systematic review and meta-analysis to assess the effectiveness of prophylactic antibiotic redosing in lengthy surgical procedures.<h4>Methods</h4>We systematically searched the PubMed, Cochrane Library, Web of Science, and Ichushi-Web databases for articles published until 31 December, 2023. We compared the incidence of SSI between patients receiving and not receiving intraoperative redosing of antibiotics in surgeries lasting ≥3 h. Subgroup analyses were conducted across study characteristics. Odds ratios (ORs) and 95% c2025-01-01T00:00:00Z2025 Mar2025-04-05T14:30:44.693Z2025-04-05T14:30:44.693ZS-EPMC118773484004653210.1002/ags3.12866