{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chaudhry SA"],"funding":["NCATS NIH HHS","NHLBI NIH HHS"],"pagination":["1423-1432"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11877412"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["333(16)"],"pubmed_abstract":["<h4>Importance</h4>Clinical decision-making in thrombotic disorders is impeded by long-standing uncertainty regarding the magnitude of venous and arterial thrombosis risk associated with low protein S. Population-scale multiomic datasets offer an unprecedented opportunity to answer questions regarding the epidemiology and clinical impacts of protein S deficiency.<h4>Objective</h4>To evaluate the risk associated with protein S deficiency across multiple thrombosis phenotypes.<h4>Design, setting, and participants</h4>Cross-sectional study using longitudinal population cohorts derived from the UK Biobank (n = 426 436) and the US National Institutes of Health All of Us (n = 204 006) biorepositories. UK Biobank participants were enrolled in 2006-2010 (last follow-up, May 19, 2020) and underwent"],"journal":["JAMA"],"pubmed_title":["Population-Scale Studies of Protein S Abnormalities and Thrombosis."],"pmcid":["PMC11877412"],"funding_grant_id":["R03 HL162761","R01 HL157635","T32 HL007227","R01 HL166246","L70 HL175855","R01 HL171042","UL1 TR001863","R01 HL092577"],"pubmed_authors":["Rodriguez Espada A","Choi SH","Ryu J","Chaudhry SA","Bauer KA","Jurgens SJ","Ellinor PT","Wang X","Bendapudi PK","Haj AK","Grover SP","Sanna-Cherchi S"],"additional_accession":[]},"is_claimable":false,"name":"Population-Scale Studies of Protein S Abnormalities and Thrombosis.","description":"<h4>Importance</h4>Clinical decision-making in thrombotic disorders is impeded by long-standing uncertainty regarding the magnitude of venous and arterial thrombosis risk associated with low protein S. Population-scale multiomic datasets offer an unprecedented opportunity to answer questions regarding the epidemiology and clinical impacts of protein S deficiency.<h4>Objective</h4>To evaluate the risk associated with protein S deficiency across multiple thrombosis phenotypes.<h4>Design, setting, and participants</h4>Cross-sectional study using longitudinal population cohorts derived from the UK Biobank (n = 426 436) and the US National Institutes of Health All of Us (n = 204 006) biorepositories. UK Biobank participants were enrolled in 2006-2010 (last follow-up, May 19, 2020) and underwent","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-05-29T08:33:52.954Z","creation":"2026-04-08T04:09:23.263Z"},"accession":"S-EPMC11877412","cross_references":{"pubmed":["40029645"],"doi":["10.1001/jama.2025.0155"]}}