biostudies-literatureChaudhry SANCATS NIH HHSNHLBI NIH HHS1423-1432https://www.ebi.ac.uk/biostudies/studies/S-EPMC11877412biostudies-literatureUnknown333(16)<h4>Importance</h4>Clinical decision-making in thrombotic disorders is impeded by long-standing uncertainty regarding the magnitude of venous and arterial thrombosis risk associated with low protein S. Population-scale multiomic datasets offer an unprecedented opportunity to answer questions regarding the epidemiology and clinical impacts of protein S deficiency.<h4>Objective</h4>To evaluate the risk associated with protein S deficiency across multiple thrombosis phenotypes.<h4>Design, setting, and participants</h4>Cross-sectional study using longitudinal population cohorts derived from the UK Biobank (n = 426 436) and the US National Institutes of Health All of Us (n = 204 006) biorepositories. UK Biobank participants were enrolled in 2006-2010 (last follow-up, May 19, 2020) and underwentJAMAPopulation-Scale Studies of Protein S Abnormalities and Thrombosis.PMC11877412R03 HL162761R01 HL157635T32 HL007227R01 HL166246L70 HL175855R01 HL171042UL1 TR001863R01 HL092577Rodriguez Espada AChoi SHRyu JChaudhry SABauer KAJurgens SJEllinor PTWang XBendapudi PKHaj AKGrover SPSanna-Cherchi SfalsePopulation-Scale Studies of Protein S Abnormalities and Thrombosis.<h4>Importance</h4>Clinical decision-making in thrombotic disorders is impeded by long-standing uncertainty regarding the magnitude of venous and arterial thrombosis risk associated with low protein S. Population-scale multiomic datasets offer an unprecedented opportunity to answer questions regarding the epidemiology and clinical impacts of protein S deficiency.<h4>Objective</h4>To evaluate the risk associated with protein S deficiency across multiple thrombosis phenotypes.<h4>Design, setting, and participants</h4>Cross-sectional study using longitudinal population cohorts derived from the UK Biobank (n = 426 436) and the US National Institutes of Health All of Us (n = 204 006) biorepositories. UK Biobank participants were enrolled in 2006-2010 (last follow-up, May 19, 2020) and underwent2025-01-01T00:00:00Z2025 Apr2026-05-29T08:33:52.954Z2026-04-08T04:09:23.263ZS-EPMC118774124002964510.1001/jama.2025.0155