{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang S"],"funding":["Japan Society for the Promotion of Science"],"pagination":["gkaf135"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11879439"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["53(5)"],"pubmed_abstract":["We discovered that the Z-form DNA-RNA hybrid stabilized by methylated CpG repeats impacts on the initiation and elongation of Okazaki fragments, contributing to blocking DNA replication at first time. We further present the first Z-form DNA-RNA hybrid structure by using NMR spectroscopy and dynamic computation, revealing the molecular mechanism of inhibition, indicating that a distinctive zig-zag strand pattern of the Z-form hybrid with a smaller helical diameter (15 Å) and a very narrow minor groove (8.3 Å) plays the key role in the repression toward DNA replication."],"journal":["Nucleic acids research"],"pubmed_title":["Z-form DNA-RNA hybrid blocks DNA replication."],"pmcid":["PMC11879439"],"funding_grant_id":["24K01648","21H02081"],"pubmed_authors":["Wang S","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Z-form DNA-RNA hybrid blocks DNA replication.","description":"We discovered that the Z-form DNA-RNA hybrid stabilized by methylated CpG repeats impacts on the initiation and elongation of Okazaki fragments, contributing to blocking DNA replication at first time. We further present the first Z-form DNA-RNA hybrid structure by using NMR spectroscopy and dynamic computation, revealing the molecular mechanism of inhibition, indicating that a distinctive zig-zag strand pattern of the Z-form hybrid with a smaller helical diameter (15 Å) and a very narrow minor groove (8.3 Å) plays the key role in the repression toward DNA replication.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-01T11:16:45.37Z","creation":"2025-04-07T11:26:53.212Z"},"accession":"S-EPMC11879439","cross_references":{"pubmed":["40037715"],"doi":["10.1093/nar/gkaf135"]}}