biostudies-literatureUnknown8Lea IALow molecular weight <i>ortho</i>-phthalates have been implicated in perturbing androgen pathways when administered during the masculinization programming window. Di-isodecyl phthalate (DIDP) is a high molecular weight phthalate and as a high production volume chemical, its ability to disrupt endocrine pathways is important to understand its potential hazard. Both DIDP (and its metabolites) were evaluated to determine the potential to perturb endocrine pathways through a weight of evidence (WoE) assessment in accordance with the European Chemicals Agency (ECHA)/European Food Safety Authority (EFSA) Endocrine Disruptor Guidance (2018). A literature review was performed of toxicological data for DIDP related to estrogen, androgen, thyroid, or steroidogenesis pathways. Literature searches retCurrent research in toxicology100221https://www.ebi.ac.uk/biostudies/studies/S-EPMC11879679biostudies-literatureEvaluation of the endocrine disrupting potential of Di-isodecyl phthalate.PMC11879679Feifarek DBorghoff SJPalermo CNyambego HHaws LLea IAMihalchik AGoyak KHeintz MfalseEvaluation of the endocrine disrupting potential of Di-isodecyl phthalate.Low molecular weight <i>ortho</i>-phthalates have been implicated in perturbing androgen pathways when administered during the masculinization programming window. Di-isodecyl phthalate (DIDP) is a high molecular weight phthalate and as a high production volume chemical, its ability to disrupt endocrine pathways is important to understand its potential hazard. Both DIDP (and its metabolites) were evaluated to determine the potential to perturb endocrine pathways through a weight of evidence (WoE) assessment in accordance with the European Chemicals Agency (ECHA)/European Food Safety Authority (EFSA) Endocrine Disruptor Guidance (2018). A literature review was performed of toxicological data for DIDP related to estrogen, androgen, thyroid, or steroidogenesis pathways. Literature searches ret2025-01-01T00:00:00Z20252025-04-19T17:33:22.094Z2025-04-19T17:33:22.094ZS-EPMC118796794004103310.1016/j.crtox.2025.100221