{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["333(9)"],"submitter":["Zeng Z"],"pubmed_abstract":["<h4>Importance</h4>Previous studies have demonstrated the advantages of short-term histopathological outcomes and complications associated with transanal total mesorectal excision (TME) compared with laparoscopic TME. However, the long-term oncological outcomes of transanal TME remain ambiguous. This study aims to compare 3-year disease-free survival of transanal TME with laparoscopic TME.<h4>Objective</h4>To evaluate 3-year disease-free survival between transanal TME and laparoscopic TME in patients with rectal cancer.<h4>Design, setting, and participants</h4>This randomized, open-label, noninferiority, phase 3 clinical trial was performed in 16 different centers in China. Between April 2016 and June 2021, a total of 1115 patients with clinical stage I to III mid-low rectal cancer were en"],"journal":["JAMA"],"pagination":["774-783"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11880948"],"repository":["biostudies-literature"],"pubmed_title":["Transanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical Trial."],"pmcid":["PMC11880948"],"pubmed_authors":["Wu M","Shi L","Zheng HC","Zhang H","Zhang YW","Huang M","Ouyang J","Huang L","Wang J","Wang Q","Wang XQ","Gu L","Cai ZH","Liu DS","Wang Y","Cong JC","Zhan L","Kang L","Wu X","Xu FP","Zheng X","Xu Q","Chen GQ","Zeng Z","Xie M","Xu FJ","Li M","Yang Z","Lan P","Gao K","Hu H","Yang R","Liu H","Yang XH","Lu JY","Chen JH","Feng B","Chinese Transanal Endoscopic Surgery Collaborative (CTESC) Group","Hou Y","Gong Y","Liu X","Zhou DB","Liu Y","Liu Z","Li ZB","Qian JJ","Ye JW","Zhang JX","Ren M","Song Y","Xiao Y","Ling L","Ren D","Tong W","Tang RX","Wu MY","Huang Z","Zhang Y","Zhang X","Peng MY","Tian Y","Fu J","Cai Y","Lai S","Luo S","Ma D","Peng J"],"additional_accession":[]},"is_claimable":false,"name":"Transanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical Trial.","description":"<h4>Importance</h4>Previous studies have demonstrated the advantages of short-term histopathological outcomes and complications associated with transanal total mesorectal excision (TME) compared with laparoscopic TME. However, the long-term oncological outcomes of transanal TME remain ambiguous. This study aims to compare 3-year disease-free survival of transanal TME with laparoscopic TME.<h4>Objective</h4>To evaluate 3-year disease-free survival between transanal TME and laparoscopic TME in patients with rectal cancer.<h4>Design, setting, and participants</h4>This randomized, open-label, noninferiority, phase 3 clinical trial was performed in 16 different centers in China. Between April 2016 and June 2021, a total of 1115 patients with clinical stage I to III mid-low rectal cancer were en","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-03-31T10:29:33.978Z","creation":"2025-08-23T03:09:30.147Z"},"accession":"S-EPMC11880948","cross_references":{"pubmed":["39847361"],"doi":["10.1001/jama.2024.24276"]}}