biostudies-literatureUnknown50(2)Xie Y<h4>Background</h4>Nonsuicidal self-injury (NSSI) is posited to arise from a complex interaction of biopsychosocial factors, with impulsivity playing a critical role. Given that current research on the neural mechanisms underlying this hypothesis remains inconsistent and limited in scope, we sought to explore how NSSI behaviours are associated with impulsivity resulting from structural brain alterations.<h4>Methods</h4>We recruited patients with NSSI behaviours and healthy controls from 11 psychiatric hospitals. We assessed the differences in impulse control between the 2 groups using the Barratt Impulsiveness Scale version 11 and the Attention Network Test. We also conducted <i>T</i> ₁-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging. Finally, we analyzed Journal of psychiatry & neuroscience : JPNE73-E84https://www.ebi.ac.uk/biostudies/studies/S-EPMC11882201biostudies-literatureImpulse control deficits among patients with nonsuicidal self-injury: a mediation analysis based on structural imaging.PMC11882201Lv ZLi JXie YLang NLong JWang COuyang LZhang LHang YZhang PLiu YYu BZhang YWang SWu SLiang MZhang CWu YfalseImpulse control deficits among patients with nonsuicidal self-injury: a mediation analysis based on structural imaging.<h4>Background</h4>Nonsuicidal self-injury (NSSI) is posited to arise from a complex interaction of biopsychosocial factors, with impulsivity playing a critical role. Given that current research on the neural mechanisms underlying this hypothesis remains inconsistent and limited in scope, we sought to explore how NSSI behaviours are associated with impulsivity resulting from structural brain alterations.<h4>Methods</h4>We recruited patients with NSSI behaviours and healthy controls from 11 psychiatric hospitals. We assessed the differences in impulse control between the 2 groups using the Barratt Impulsiveness Scale version 11 and the Attention Network Test. We also conducted <i>T</i> ₁-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging. Finally, we analyzed 2025-01-01T00:00:00Z2025 Mar-Apr2025-04-04T20:24:35.617Z2025-04-04T20:24:35.617ZS-EPMC118822014003766010.1503/jpn.240129