biostudies-literatureYe XSichuan Province Innovative Talent Funding Project for Postdoctoral FellowsXinglin Talent Program of Chengdu University of Traditional Chinese MedicineNational Natural Science Foundation of ChinaChina Postdoctoral Science FoundationChina National Postdoctoral Program For Innovative TalentsNatural Science Foundation of Sichuan Provinceuhae327https://www.ebi.ac.uk/biostudies/studies/S-EPMC11883231biostudies-literatureUnknown12(3)The genus <i>Paris</i>, comprising a series of distinctive medicinal plants, has been utilized globally for its therapeutic properties over centuries. Modern pharmacological studies have demonstrated that secondary metabolites from <i>Paris</i> species exhibit significant pharmacological activities, including anticancer, hemostatic, anti-inflammatory, antimicrobial, and other effects. Additionally, the unique morphological traits and large genome size of <i>Paris</i> species have continuously captured the interest of botanists and horticulturalists. Nonetheless, the conservation of wild <i>Paris</i> populations is threatened due to the lengthy reproductive cycle and overexploitation, posing considerable challenges to their development and sustainable use. This review provides a comprehensiHorticulture researchThe genus &lt;i&gt;Paris&lt;/i&gt;: a fascinating resource for medicinal and botanical studies.PMC1188323182222072, U1902214, 32300318, and 824046052022 M720546, 2022MD723713, and GZC20230332BSH2023030BX20220048BX2023182024NSFSC1324, 2022NSFSC1362, 24NSFSC4937, and 2022JDJQ0055Liu YPu XLTan XChen JTao YHu HLi SHTan CLYe XfalseThe genus &lt;i&gt;Paris&lt;/i&gt;: a fascinating resource for medicinal and botanical studies.The genus <i>Paris</i>, comprising a series of distinctive medicinal plants, has been utilized globally for its therapeutic properties over centuries. Modern pharmacological studies have demonstrated that secondary metabolites from <i>Paris</i> species exhibit significant pharmacological activities, including anticancer, hemostatic, anti-inflammatory, antimicrobial, and other effects. Additionally, the unique morphological traits and large genome size of <i>Paris</i> species have continuously captured the interest of botanists and horticulturalists. Nonetheless, the conservation of wild <i>Paris</i> populations is threatened due to the lengthy reproductive cycle and overexploitation, posing considerable challenges to their development and sustainable use. This review provides a comprehensi2025-01-01T00:00:00Z2025 Mar2025-04-05T11:18:05.027Z2025-04-05T11:18:05.027ZS-EPMC118832314005157810.1093/hr/uhae327