{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Q"],"funding":["Proof of Concept of Jilin University","National Natural Science Foundation of China","Science and Technology Department Project of Jilin Province","Project of \"Medical+X\" Interdisciplinary Innovation Team of Norman Bethune Health Science Center of Jilin University","Youth Innovation Promotion Association of the Chinese Academy of Sciences"],"pagination":["e2412561"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11884576"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(9)"],"pubmed_abstract":["Dentin hypersensitivity (DH), marked by exposed dentinal tubules, presents as a sharp toothache triggered by stimuli and subsides when the stimuli are removed. To address the limitations of current commercial desensitizers in terms of acid resistance, friction resistance, and stability, a black phosphorus nanosheet-composited methacrylate gelatin hydrogel (GelMA/BP) is developed for DH treatment, leveraging the synergistic effects of photothermal therapy and biomineralization. Incorporating the BP nanosheet provided GelMA/BP with a stable photothermal response and the continuous release of phosphate anions, which blocked dentinal tubules by converting light energy into heat and initiating biomineralization. In vitro desensitizing therapy showed that the dentinal tubule diameter in the GelM"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Photothermal Effect and Biomineralization of Black Phosphorus Nanosheet-Composited Hydrogel Boosts Synergistic Treatment of Dentin Hypersensitivity."],"pmcid":["PMC11884576"],"funding_grant_id":["2022JBGS06","2023GN0027","YDZJ202401282ZYTS","Y2023066","20240101002JJ","20230203085SF","U21A2099"],"pubmed_authors":["Li X","Wang Q","Li D","Wang G","Zhang C","Ding J"],"additional_accession":[]},"is_claimable":false,"name":"Photothermal Effect and Biomineralization of Black Phosphorus Nanosheet-Composited Hydrogel Boosts Synergistic Treatment of Dentin Hypersensitivity.","description":"Dentin hypersensitivity (DH), marked by exposed dentinal tubules, presents as a sharp toothache triggered by stimuli and subsides when the stimuli are removed. To address the limitations of current commercial desensitizers in terms of acid resistance, friction resistance, and stability, a black phosphorus nanosheet-composited methacrylate gelatin hydrogel (GelMA/BP) is developed for DH treatment, leveraging the synergistic effects of photothermal therapy and biomineralization. Incorporating the BP nanosheet provided GelMA/BP with a stable photothermal response and the continuous release of phosphate anions, which blocked dentinal tubules by converting light energy into heat and initiating biomineralization. In vitro desensitizing therapy showed that the dentinal tubule diameter in the GelM","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-05T11:18:04.796Z","creation":"2025-04-05T11:18:04.796Z"},"accession":"S-EPMC11884576","cross_references":{"pubmed":["39749636"],"doi":["10.1002/advs.202412561"]}}