biostudies-literatureLi AScience and Technology Commission of Shanghai MunicipalityCooperation Program of the Xuhui District Medical College with EnterprisesProgram of National Key Research and DevelopmentYoung Scientists Fund of the National Natural Science Foundation of ChinaNational Natural Science Foundation of Chinae2414307https://www.ebi.ac.uk/biostudies/studies/S-EPMC11884613biostudies-literatureUnknown12(9)Pulmonary metastasis represents one of the most prevalent forms of metastasis in advanced melanoma, with mortality rates reaching 70%. Current treatments including chemotherapy, targeted therapy, and immunotherapy frequently exhibit limited efficacy or present high costs. To address these clinical needs, this study presents a biomimetic drug delivery system (Ce6-pTP-CsA) utilizing cryoshocked adipocytes (CsA) encapsulating the prodrug triptolide palmitate (pTP) and the photosensitizer Ce6, exploiting the characteristic of tumor cells to recruit and lipolyze adipocytes for energy. CsA substantially enhances the drug-loading capacity of adipocytes, with its particle size characteristics enabling targeted delivery of pTP to the lungs. The combination of photodynamic therapy (PDT) and pTP actiAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Cryoshocked Adipocytes Mediated Dual-Modal Strategy Combining Photodynamic Therapy and Triptolide Palmitate for Pulmonary Metastatic Melanoma Treatment.PMC118846132023YFC340410323XHYD-2482274103823050398207427224S1190150023S21900200Liu JLi DGu YQi FHe MLi ALiu RZeng YCai HfalseCryoshocked Adipocytes Mediated Dual-Modal Strategy Combining Photodynamic Therapy and Triptolide Palmitate for Pulmonary Metastatic Melanoma Treatment.Pulmonary metastasis represents one of the most prevalent forms of metastasis in advanced melanoma, with mortality rates reaching 70%. Current treatments including chemotherapy, targeted therapy, and immunotherapy frequently exhibit limited efficacy or present high costs. To address these clinical needs, this study presents a biomimetic drug delivery system (Ce6-pTP-CsA) utilizing cryoshocked adipocytes (CsA) encapsulating the prodrug triptolide palmitate (pTP) and the photosensitizer Ce6, exploiting the characteristic of tumor cells to recruit and lipolyze adipocytes for energy. CsA substantially enhances the drug-loading capacity of adipocytes, with its particle size characteristics enabling targeted delivery of pTP to the lungs. The combination of photodynamic therapy (PDT) and pTP acti2025-01-01T00:00:00Z2025 Mar2025-04-20T01:50:55.263Z2025-04-20T01:50:55.263ZS-EPMC118846133980494110.1002/advs.202414307