biostudies-literatureGasecka AWarszawski Uniwersytet MedycznyDutch Research Council (NWO)17-27https://www.ebi.ac.uk/biostudies/studies/S-EPMC11885366biostudies-literatureUnknown18(1)Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the predictive value of advanced glycation end products (AGEs) and plasma concentrations of extracellular vesicles (EVs) for the systolic and diastolic dysfunction progression in HFmrEF patients. Skin AGE accumulation was measured using AGE Reader. Plasma EV concentrations were measured using flow cytometry. Among 74 patients enrolled, 13 (18%) had systolic dysfunction progression and 5 (7%) had diastolic dysfunction progression during 6.5 months follow-up. Leukocyte EVs concentrations were higher in patients with systolic dysfunction progression (p = 0.002) and predicted the progression with 75.0% sensitivity and 58.3% specificity, independent of other clinical variables (Journal of cardiovascular translational researchLeukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) - A Prospective, Multicentre Cohort Study.PMC11885366VIDI 197241WR/2/M/MB/N/22Gajewska MGozdowska RSiniarski AZajkowska DGrabowski MKaraban KRogula SFilipiak KJKleibert Mvan der Pol EStepien KDuchnowski PGasecka ABlazejowska EGrat MPorebska KReda ANieuwland RRolek BSlupik DfalseLeukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) - A Prospective, Multicentre Cohort Study.Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the predictive value of advanced glycation end products (AGEs) and plasma concentrations of extracellular vesicles (EVs) for the systolic and diastolic dysfunction progression in HFmrEF patients. Skin AGE accumulation was measured using AGE Reader. Plasma EV concentrations were measured using flow cytometry. Among 74 patients enrolled, 13 (18%) had systolic dysfunction progression and 5 (7%) had diastolic dysfunction progression during 6.5 months follow-up. Leukocyte EVs concentrations were higher in patients with systolic dysfunction progression (p = 0.002) and predicted the progression with 75.0% sensitivity and 58.3% specificity, independent of other clinical variables (2025-01-01T00:00:00Z2025 Feb2025-07-12T03:04:25.57Z2025-04-04T00:26:32.183ZS-EPMC118853663931627110.1007/s12265-024-10561-3