{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi I"],"funding":["National Research Foundation of Korea (NRF)"],"pagination":["2308"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11889129"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Decision-making in mammals fundamentally relies on integrating multiple sensory inputs, with conflicting information resolved flexibly based on a dominant sensory modality. However, the neural mechanisms underlying state-dependent changes in sensory dominance remain poorly understood. Our study demonstrates that locomotion in mice shifts auditory-dominant decisions toward visual dominance during audiovisual conflicts. Using circuit-specific calcium imaging and optogenetic manipulations, we found that weakened visual representation in the posterior parietal cortex (PPC) leads to auditory-dominant decisions in stationary mice. Prolonged locomotion, however, promotes visual dominance by inhibiting auditory cortical neurons projecting to the PPC (AC<sub>PPC</sub>). This shift is mediated by se"],"journal":["Nature communications"],"pubmed_title":["Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions."],"pmcid":["PMC11889129"],"funding_grant_id":["NRF-2021R1A2C3012159"],"pubmed_authors":["Lee SH","Choi I"],"additional_accession":[]},"is_claimable":false,"name":"Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions.","description":"Decision-making in mammals fundamentally relies on integrating multiple sensory inputs, with conflicting information resolved flexibly based on a dominant sensory modality. However, the neural mechanisms underlying state-dependent changes in sensory dominance remain poorly understood. Our study demonstrates that locomotion in mice shifts auditory-dominant decisions toward visual dominance during audiovisual conflicts. Using circuit-specific calcium imaging and optogenetic manipulations, we found that weakened visual representation in the posterior parietal cortex (PPC) leads to auditory-dominant decisions in stationary mice. Prolonged locomotion, however, promotes visual dominance by inhibiting auditory cortical neurons projecting to the PPC (AC<sub>PPC</sub>). This shift is mediated by se","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T00:26:28.673Z","creation":"2025-04-04T00:26:28.673Z"},"accession":"S-EPMC11889129","cross_references":{"pubmed":["40055344"],"doi":["10.1038/s41467-025-57347-y"]}}