biostudies-literatureChoi INational Research Foundation of Korea (NRF)2308https://www.ebi.ac.uk/biostudies/studies/S-EPMC11889129biostudies-literatureUnknown16(1)Decision-making in mammals fundamentally relies on integrating multiple sensory inputs, with conflicting information resolved flexibly based on a dominant sensory modality. However, the neural mechanisms underlying state-dependent changes in sensory dominance remain poorly understood. Our study demonstrates that locomotion in mice shifts auditory-dominant decisions toward visual dominance during audiovisual conflicts. Using circuit-specific calcium imaging and optogenetic manipulations, we found that weakened visual representation in the posterior parietal cortex (PPC) leads to auditory-dominant decisions in stationary mice. Prolonged locomotion, however, promotes visual dominance by inhibiting auditory cortical neurons projecting to the PPC (AC_PPC). This shift is mediated by seNature communicationsLocomotion-dependent auditory gating to the parietal cortex guides multisensory decisions.PMC11889129NRF-2021R1A2C3012159Lee SHChoi IfalseLocomotion-dependent auditory gating to the parietal cortex guides multisensory decisions.Decision-making in mammals fundamentally relies on integrating multiple sensory inputs, with conflicting information resolved flexibly based on a dominant sensory modality. However, the neural mechanisms underlying state-dependent changes in sensory dominance remain poorly understood. Our study demonstrates that locomotion in mice shifts auditory-dominant decisions toward visual dominance during audiovisual conflicts. Using circuit-specific calcium imaging and optogenetic manipulations, we found that weakened visual representation in the posterior parietal cortex (PPC) leads to auditory-dominant decisions in stationary mice. Prolonged locomotion, however, promotes visual dominance by inhibiting auditory cortical neurons projecting to the PPC (AC_PPC). This shift is mediated by se2025-01-01T00:00:00Z2025 Mar2025-04-04T00:26:28.673Z2025-04-04T00:26:28.673ZS-EPMC118891294005534410.1038/s41467-025-57347-y