{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["El Bounkari O"],"pubmed_abstract":["Atherosclerosis is the underlying cause of myocardial infarction and ischemic stroke. It is a lipid-triggered and cytokine/chemokine-driven arterial inflammatory condition. We identify D-dopachrome tautomerase/macrophage migration-inhibitory factor-2 (MIF-2), a paralog of the cytokine MIF, as an atypical chemokine promoting both atherosclerosis and hepatic lipid accumulation. In hyperlipidemic Apoe<sup>-/-</sup> mice, Mif-2-deficiency and pharmacological MIF-2-blockade protect against lesion formation and vascular inflammation in early and advanced atherogenesis. MIF-2 promotes leukocyte migration, endothelial arrest, and foam-cell formation, and we identify CXCR4 as a receptor for MIF-2. Mif-2-deficiency in Apoe<sup>-/-</sup> mice leads to decreased plasma lipid levels and suppressed hepa"],"journal":["Nature communications"],"pagination":["2297"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11889166"],"repository":["biostudies-literature"],"pubmed_title":["An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis."],"pmcid":["PMC11889166"],"pubmed_authors":["Kempf WE","Haid M","Kontos C","Brandhofer M","Bucala R","Schulz C","Zan C","Zarwel M","Hoffmann A","El Bounkari O","Rath D","Riols F","Sachs N","Harm T","Gokce O","Ji H","Megens RTA","Bourilhon P","Weber C","Yang B","Wagner J","Messerer D","Ebert S","Bugar E","Kapurniotu A","Bernhagen J","Jansen Y","Doring Y","Avdic M","Gawaz M","Gerra S","Kramer N","Maegdefessel L","Sinitski D","Milic J","Bartelt A","Willemsen N"],"additional_accession":[]},"is_claimable":false,"name":"An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis.","description":"Atherosclerosis is the underlying cause of myocardial infarction and ischemic stroke. It is a lipid-triggered and cytokine/chemokine-driven arterial inflammatory condition. We identify D-dopachrome tautomerase/macrophage migration-inhibitory factor-2 (MIF-2), a paralog of the cytokine MIF, as an atypical chemokine promoting both atherosclerosis and hepatic lipid accumulation. In hyperlipidemic Apoe<sup>-/-</sup> mice, Mif-2-deficiency and pharmacological MIF-2-blockade protect against lesion formation and vascular inflammation in early and advanced atherogenesis. MIF-2 promotes leukocyte migration, endothelial arrest, and foam-cell formation, and we identify CXCR4 as a receptor for MIF-2. Mif-2-deficiency in Apoe<sup>-/-</sup> mice leads to decreased plasma lipid levels and suppressed hepa","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-01T05:06:50.549Z","creation":"2025-04-04T13:11:35.598Z"},"accession":"S-EPMC11889166","cross_references":{"pubmed":["40055309"],"doi":["10.1038/s41467-025-57540-z"]}}