{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang W"],"funding":["the State Key Laboratory of Dampness Syndrome of Chinese Medicine","the National Natural Science Foundation of China"],"pagination":["33"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11890557"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Shi Zheng (SZ, syndrome of dampness) is a major syndrome type in traditional Chinese Medicine (TCM), the ambiguity of its pathomechanism and the lack of blood diagnostic indicators have limited the understanding of the development of SZ.<h4>Purpose</h4>To explore the pathological mechanism of SZ and establish a symptom-centered diagnosis and treatment model.<h4>Methods</h4>We recruited 250 participants, including healthy individuals and patients diagnosed with SZ. Serum metabolomics and proteomics analyses were performed to screen common pathways. Along with the biological significance of common pathways, a common pathway-symptom correlation diagram was constructed to elucidate the pathological mechanism underlying the occurrence and development of SZ. The enrichment sco"],"journal":["Chinese medicine"],"pubmed_title":["Multi-omics driven paradigm for construction of traditional Chinese Medicine Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example."],"pmcid":["PMC11890557"],"funding_grant_id":["SZ2021ZZ49","82404816","U23A20501","SZ2022KF16"],"pubmed_authors":["Chen Q","Yang L","Han Y","Sun Y","Li W","Guo J","Ren J","Wei S","Lin F","Wang W","Chen Y","Wang X","Sun H","Yan G"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omics driven paradigm for construction of traditional Chinese Medicine Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example.","description":"<h4>Background</h4>Shi Zheng (SZ, syndrome of dampness) is a major syndrome type in traditional Chinese Medicine (TCM), the ambiguity of its pathomechanism and the lack of blood diagnostic indicators have limited the understanding of the development of SZ.<h4>Purpose</h4>To explore the pathological mechanism of SZ and establish a symptom-centered diagnosis and treatment model.<h4>Methods</h4>We recruited 250 participants, including healthy individuals and patients diagnosed with SZ. Serum metabolomics and proteomics analyses were performed to screen common pathways. Along with the biological significance of common pathways, a common pathway-symptom correlation diagram was constructed to elucidate the pathological mechanism underlying the occurrence and development of SZ. The enrichment sco","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T08:22:46.173Z","creation":"2025-04-04T08:22:46.173Z"},"accession":"S-EPMC11890557","cross_references":{"pubmed":["40057776"],"doi":["10.1186/s13020-025-01085-2"]}}