biostudies-literatureWang Wthe State Key Laboratory of Dampness Syndrome of Chinese Medicinethe National Natural Science Foundation of China33https://www.ebi.ac.uk/biostudies/studies/S-EPMC11890557biostudies-literatureUnknown20(1)<h4>Background</h4>Shi Zheng (SZ, syndrome of dampness) is a major syndrome type in traditional Chinese Medicine (TCM), the ambiguity of its pathomechanism and the lack of blood diagnostic indicators have limited the understanding of the development of SZ.<h4>Purpose</h4>To explore the pathological mechanism of SZ and establish a symptom-centered diagnosis and treatment model.<h4>Methods</h4>We recruited 250 participants, including healthy individuals and patients diagnosed with SZ. Serum metabolomics and proteomics analyses were performed to screen common pathways. Along with the biological significance of common pathways, a common pathway-symptom correlation diagram was constructed to elucidate the pathological mechanism underlying the occurrence and development of SZ. The enrichment scoChinese medicineMulti-omics driven paradigm for construction of traditional Chinese Medicine Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example.PMC11890557SZ2021ZZ4982404816U23A20501SZ2022KF16Chen QYang LHan YSun YLi WGuo JRen JWei SLin FWang WChen YWang XSun HYan GfalseMulti-omics driven paradigm for construction of traditional Chinese Medicine Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example.<h4>Background</h4>Shi Zheng (SZ, syndrome of dampness) is a major syndrome type in traditional Chinese Medicine (TCM), the ambiguity of its pathomechanism and the lack of blood diagnostic indicators have limited the understanding of the development of SZ.<h4>Purpose</h4>To explore the pathological mechanism of SZ and establish a symptom-centered diagnosis and treatment model.<h4>Methods</h4>We recruited 250 participants, including healthy individuals and patients diagnosed with SZ. Serum metabolomics and proteomics analyses were performed to screen common pathways. Along with the biological significance of common pathways, a common pathway-symptom correlation diagram was constructed to elucidate the pathological mechanism underlying the occurrence and development of SZ. The enrichment sco2025-01-01T00:00:00Z2025 Mar2025-04-04T08:22:46.173Z2025-04-04T08:22:46.173ZS-EPMC118905574005777610.1186/s13020-025-01085-2