{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["77(1)"],"submitter":["Patel V"],"pubmed_abstract":["The chromosomal characterization of nasopharyngeal angiofibroma (NPF) of Indian origin seems important as it is consistently absent in literature. Routine karyotyping (G-banding) and fluorescence in situ hybridization (FISH) analysis was undertaken using CMYC, TP53 CEPX/Y probes in 9 cases of NPF wherein chromosomal characteristics were correlated with clinical parameters. Karyotype profile of venous sample from every case was normal. Following FISH analysis, 5 (55%) cases showed deleted CMYC allele while 4 (44%) showed deleted TP53. In addition, loss of Y centromere was evident in 1 case. Despite definite trends, no significant correlation with clinical parameters and FISH expression/ G-banding karyotyping could be appreciated. The peripheral blood karyotype cannot predict any significant"],"journal":["Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India"],"pagination":["284-290"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11890675"],"repository":["biostudies-literature"],"pubmed_title":["Nasopharyngeal Angiofibroma: Karyotyping Profile and Florescent In-Situ Hybridization Analysis with C-Myelocytomatosis, Tumor Suppressor p53 and CEP-X/Y Probes."],"pmcid":["PMC11890675"],"pubmed_authors":["Singh MK","Mishra A","Patel V"],"additional_accession":[]},"is_claimable":false,"name":"Nasopharyngeal Angiofibroma: Karyotyping Profile and Florescent In-Situ Hybridization Analysis with C-Myelocytomatosis, Tumor Suppressor p53 and CEP-X/Y Probes.","description":"The chromosomal characterization of nasopharyngeal angiofibroma (NPF) of Indian origin seems important as it is consistently absent in literature. Routine karyotyping (G-banding) and fluorescence in situ hybridization (FISH) analysis was undertaken using CMYC, TP53 CEPX/Y probes in 9 cases of NPF wherein chromosomal characteristics were correlated with clinical parameters. Karyotype profile of venous sample from every case was normal. Following FISH analysis, 5 (55%) cases showed deleted CMYC allele while 4 (44%) showed deleted TP53. In addition, loss of Y centromere was evident in 1 case. Despite definite trends, no significant correlation with clinical parameters and FISH expression/ G-banding karyotyping could be appreciated. The peripheral blood karyotype cannot predict any significant","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-05-27T08:00:45.733Z","creation":"2026-05-27T03:12:22.322Z"},"accession":"S-EPMC11890675","cross_references":{"pubmed":["40066402"],"doi":["10.1007/s12070-024-05171-z"]}}