{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Zhou R"],"pubmed_abstract":["<h4>Background</h4>Previous evidence suggests that methionine (Met) consumption can promote placental angiogenesis and improve fetal survival. To investigate the mechanisms by which increased levels of Met as hydroxyl-Met (OHMet) improve placental function, forty sows were divided into four groups and fed either a control diet, or diets supplemented with 0.15% OHMet, 0.3% OHMet or 0.3% Met (n = 10). Placentas were collected immediately after expulsion, and extracted proteins were analyzed by tandem mass tag based quantitative proteomic analysis.<h4>Results</h4>We found that 0.15% OHMet consumption significantly increased placental vascular density compared with the control. Proteomic analysis identified 5,136 proteins, 87 of these were differentially expressed (P < 0.05, |fold change| > 1."],"journal":["Journal of animal science and biotechnology"],"pagination":["39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11890719"],"repository":["biostudies-literature"],"pubmed_title":["Increased maternal consumption of methionine as its hydroxyl analog improves placental angiogenesis and antioxidative capacity in sows."],"pmcid":["PMC11890719"],"pubmed_authors":["Yuan P","Yang L","Zhuo Y","Zhe L","Zhou R","Lin Y","Feng B","Che L","Hua L","Fang Z","Zhang X","Xu S","Lai S","Hu L","Wu","Mercier Y"],"additional_accession":[]},"is_claimable":false,"name":"Increased maternal consumption of methionine as its hydroxyl analog improves placental angiogenesis and antioxidative capacity in sows.","description":"<h4>Background</h4>Previous evidence suggests that methionine (Met) consumption can promote placental angiogenesis and improve fetal survival. To investigate the mechanisms by which increased levels of Met as hydroxyl-Met (OHMet) improve placental function, forty sows were divided into four groups and fed either a control diet, or diets supplemented with 0.15% OHMet, 0.3% OHMet or 0.3% Met (n = 10). Placentas were collected immediately after expulsion, and extracted proteins were analyzed by tandem mass tag based quantitative proteomic analysis.<h4>Results</h4>We found that 0.15% OHMet consumption significantly increased placental vascular density compared with the control. Proteomic analysis identified 5,136 proteins, 87 of these were differentially expressed (P < 0.05, |fold change| > 1.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-01T20:12:01.325Z","creation":"2025-04-07T07:53:52.203Z"},"accession":"S-EPMC11890719","cross_references":{"pubmed":["40057782"],"doi":["10.1186/s40104-025-01159-z"]}}