{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu L"],"funding":["China Postdoctoral Science Foundation","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["2339"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11890746"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Uricase (UOx)-based gout treatments are generally limited due in part to the accumulation of H<sub>2</sub>O<sub>2</sub> in an arthrosis environment characterized by a sluggish metabolism. Here we develop a self-cascade nanomotor with high efficiency toward simultaneous uric acid (UA) degradation and H<sub>2</sub>O<sub>2</sub> elimination on the basis of UOx and sodium citrate loading in amine functionalized hollow mesoporous silica nanoparticles (AHMSNs). Due to the inherent asymmetry of AHMSNs, the developed nanomotors can be actuated by ionic diffusiophoresis induced by the enzymatic UA degradation, thus enlarging the diffusion range within the joint cavity. H<sub>2</sub>O<sub>2</sub> generated during UA decomposition can be simultaneously eliminated by the loaded sodium citrate, resulti"],"journal":["Nature communications"],"pubmed_title":["Gout management using uricase and sodium citrate hollow mesoporous nanomotors."],"pmcid":["PMC11890746"],"funding_grant_id":["51973241; 22375224","22175083","22405119","2023M741595"],"pubmed_authors":["Jiang Y","Li X","Peng F","Wang P","Liu L","Gao J","Chen Y","Ye Y","Tu Y"],"additional_accession":[]},"is_claimable":false,"name":"Gout management using uricase and sodium citrate hollow mesoporous nanomotors.","description":"Uricase (UOx)-based gout treatments are generally limited due in part to the accumulation of H<sub>2</sub>O<sub>2</sub> in an arthrosis environment characterized by a sluggish metabolism. Here we develop a self-cascade nanomotor with high efficiency toward simultaneous uric acid (UA) degradation and H<sub>2</sub>O<sub>2</sub> elimination on the basis of UOx and sodium citrate loading in amine functionalized hollow mesoporous silica nanoparticles (AHMSNs). Due to the inherent asymmetry of AHMSNs, the developed nanomotors can be actuated by ionic diffusiophoresis induced by the enzymatic UA degradation, thus enlarging the diffusion range within the joint cavity. H<sub>2</sub>O<sub>2</sub> generated during UA decomposition can be simultaneously eliminated by the loaded sodium citrate, resulti","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T08:23:04.814Z","creation":"2025-04-04T08:23:04.814Z"},"accession":"S-EPMC11890746","cross_references":{"pubmed":["40057522"],"doi":["10.1038/s41467-025-56100-9"]}}