{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Adams SE"],"funding":["Unilever Oral Care"],"pubmed_abstract":["The oral microbiome is a diverse community of microbes residing on all oral surfaces. A balanced oral microbiome is associated with good oral health, and disruption can result in imbalance associated with diseases including gingivitis and dental caries. It is important, therefore, to understand how daily use of oral hygiene products impacts the microbiome. Composition and activity of dental plaque microbiome from 115 participants was analysed after brushing with one of two toothpastes, one containing zinc citrate trihydrate and the other a control toothpaste, in a parallel design. Each participant brushed twice daily for 6-weeks, with samples collected at baseline, 2 and 6-weeks. Metataxonomic analysis demonstrated changes in bacterial communities with use of the zinc toothpaste compared t"],"journal":["Scientific reports"],"pagination":["8136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11890769"],"repository":["biostudies-literature"],"pubmed_title":["A randomised, double-blind clinical study into the effect of zinc citrate trihydrate toothpaste on oral plaque microbiome ecology and function."],"pmcid":["PMC11890769"],"pubmed_authors":["Cawley AK","Marsh PD","Marriott RE","Adams SE","Arnold D","Matheson JR","Hoptroff MJ","Gemmell MR","Slomka V"],"additional_accession":[]},"is_claimable":false,"name":"A randomised, double-blind clinical study into the effect of zinc citrate trihydrate toothpaste on oral plaque microbiome ecology and function.","description":"The oral microbiome is a diverse community of microbes residing on all oral surfaces. A balanced oral microbiome is associated with good oral health, and disruption can result in imbalance associated with diseases including gingivitis and dental caries. It is important, therefore, to understand how daily use of oral hygiene products impacts the microbiome. Composition and activity of dental plaque microbiome from 115 participants was analysed after brushing with one of two toothpastes, one containing zinc citrate trihydrate and the other a control toothpaste, in a parallel design. Each participant brushed twice daily for 6-weeks, with samples collected at baseline, 2 and 6-weeks. Metataxonomic analysis demonstrated changes in bacterial communities with use of the zinc toothpaste compared t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-01T20:12:04.886Z","creation":"2025-04-07T07:53:59.647Z"},"accession":"S-EPMC11890769","cross_references":{"pubmed":["40057571"],"doi":["10.1038/s41598-025-92545-0"]}}