{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zullo AR"],"funding":["NIA NIH HHS","National Institute on Aging"],"pagination":["105439"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11890954"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(3)"],"pubmed_abstract":["<h4>Objectives</h4>Little information exists on whether nationwide efforts to reduce antipsychotic use among nursing home (NH) residents with Alzheimer's disease and related dementias improved mortality and hospitalization outcomes for residents. Our objective was to examine the effect of NH decreases in antipsychotic use on outcomes for residents with Alzheimer's disease and related dementias.<h4>Design</h4>Observational nationwide study that emulated a series of cluster randomized trials.<h4>Setting and participants</h4>Long-stay NH residents with Alzheimer's disease and related dementias in US NHs.<h4>Methods</h4>The study used data from Medicare claims to emulate cluster randomized trials in which NHs were assigned to either decrease or maintain/increase antipsychotic use. Outcome asce"],"journal":["Journal of the American Medical Directors Association"],"pubmed_title":["Effects of Nursing Home Changes in Antipsychotic Use on Outcomes among Residents with Dementia."],"pmcid":["PMC11890954"],"funding_grant_id":["R01AG065722","P01AG027296","RF1 AG089541","R01 AG077620","P01 AG027296","K08 AG071856","R01 AG088522","R01AG077620","R01 AG065722"],"pubmed_authors":["Shireman TI","Zhang T","Varma H","Gerlach LB","Bynum JPW","Coe AB","Riester MR","Thomas KS","Joshi R","Zullo AR","Daiello LA"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Nursing Home Changes in Antipsychotic Use on Outcomes among Residents with Dementia.","description":"<h4>Objectives</h4>Little information exists on whether nationwide efforts to reduce antipsychotic use among nursing home (NH) residents with Alzheimer's disease and related dementias improved mortality and hospitalization outcomes for residents. Our objective was to examine the effect of NH decreases in antipsychotic use on outcomes for residents with Alzheimer's disease and related dementias.<h4>Design</h4>Observational nationwide study that emulated a series of cluster randomized trials.<h4>Setting and participants</h4>Long-stay NH residents with Alzheimer's disease and related dementias in US NHs.<h4>Methods</h4>The study used data from Medicare claims to emulate cluster randomized trials in which NHs were assigned to either decrease or maintain/increase antipsychotic use. Outcome asce","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-07-16T23:07:46.911Z","creation":"2026-07-12T03:10:49.836Z"},"accession":"S-EPMC11890954","cross_references":{"pubmed":["39740766"],"doi":["10.1016/j.jamda.2024.105439"]}}