{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Antunes L"],"funding":["European Centre for Disease Prevention and Control"],"pagination":["e70081"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11890973"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(3)"],"pubmed_abstract":["We estimated the effectiveness of the adapted monovalent XBB.1.5 COVID-19 vaccines against PCR-confirmed SARS-CoV-2 hospitalisation during the BA.2.86/JN.1 lineage-predominant period using a multicentre test-negative case-control study in Europe. We included older adults (≥ 65 years) hospitalised with severe acute respiratory infection from November 2023 to May 2024. Vaccine effectiveness was 46% at 14-59 days and 34% at 60-119 days, with no effect thereafter. The XBB.1.5 COVID-19 vaccines conferred protection against BA.2.86 lineage hospitalisation in the first 4 months post-vaccination."],"journal":["Influenza and other respiratory viruses"],"pubmed_title":["Effectiveness of the XBB.1.5 COVID-19 Vaccines Against SARS-CoV-2 Hospitalisation Among Adults Aged ≥ 65 Years During the BA.2.86/JN.1 Predominant Period, VEBIS Hospital Study, Europe, November 2023 to May 2024."],"pmcid":["PMC11890973"],"funding_grant_id":["ECDC/2021/016 (EU-H)","ECDC/2021/016 (EU‐H)"],"pubmed_authors":["Cikes M","Preuss U","Duffy R","Mladinov S","Krisztalovics K","Kosa-Tudor AG","Andry L","Delaere B","Bauer T","Blommen M","Martinez-Baz I","Nonkovic D","Sion C","Borg ML","Husa P","Navascues A","Medic A","Novosel IP","Tomas I","Luca MC","Jancoriene L","Tavares M","Cesar HC","Guiomar R","Bourgeois M","Mickiene A","Barbara C","de Lacerda AP","De Waegemaeker P","Tolksdorf K","Turi G","VEBIS SARI VE network team","De Koster S","Howard J","Dockx Y","Durrwald R","Parys A","Varga C","Maia E Silva SC","Bleyen M","Domegan L","Verdasca N","Denayer S","Cincileviciute G","Florescu SA","Basile L","Dinu S","Trobajo-Sanmartin C","Buda S","Souckova L","Petric PT","Rojas-Castro M","Xuereb G","Pereira D","Vilain A","Jukic I","Nicolay N","Seyler L","Pascu C","Necsoi C","Dauby N","Dziugyte A","Dorobat CM","Fernandez-Huerta M","Leroux-Roels I","Rodrigues AP","Tabain I","Marin A","Naesens R","Oprea M","Toure Y","Bacci S","Krieger D","Ezpeleta C","Karabuva S","Holemans X","Geeroms S","Pinto P","Ezpeleta G","Henriques C","Ternest S","Zablockiene B","Brugerolles C","Bossuyt N","Makaric ZL","Cenoz MG","Melillo T","Kubiliute I","Tardei G","Oh DY","Hackmann C","Fatukasi T","Reynders M","Demuyser T","Fitzgerald M","Daelemans S","Petrovic G","Antunes L","Mlinaric I","Radas J","Markic J","Delvallee M","Slekyte G","Jouck D","Majauskaite F","Casado I","Popescu C","Loghin II","Jansens H","Vaikutyte R","Kuliese M","Rose AMC","Bistriceanu I","Machado A","Fenyves B","Oroszi B","Struyven P","Mihai ME","Horvath JK","Zablockis R","Bernaert E","Magerman K","Ceausu E","Brnas A","Castilla J","Reiche J","Witdouck A","Dufrasne F","Juhasz KM","Van Nedervelde E","Abela S","Lozano M","Tonkic M","Bocina I","Gomez V","Ivanciuc A","Lazar M","Nikolic M","Echeverria A","Matheeussen V","Martin C","De Mot L","Petit E","Kristof K","Cauchi JP","O'Donnell J","Lissoir B","Fierens S"],"additional_accession":[]},"is_claimable":false,"name":"Effectiveness of the XBB.1.5 COVID-19 Vaccines Against SARS-CoV-2 Hospitalisation Among Adults Aged ≥ 65 Years During the BA.2.86/JN.1 Predominant Period, VEBIS Hospital Study, Europe, November 2023 to May 2024.","description":"We estimated the effectiveness of the adapted monovalent XBB.1.5 COVID-19 vaccines against PCR-confirmed SARS-CoV-2 hospitalisation during the BA.2.86/JN.1 lineage-predominant period using a multicentre test-negative case-control study in Europe. We included older adults (≥ 65 years) hospitalised with severe acute respiratory infection from November 2023 to May 2024. Vaccine effectiveness was 46% at 14-59 days and 34% at 60-119 days, with no effect thereafter. The XBB.1.5 COVID-19 vaccines conferred protection against BA.2.86 lineage hospitalisation in the first 4 months post-vaccination.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-06-27T03:05:41.416Z","creation":"2025-04-04T08:23:12.097Z"},"accession":"S-EPMC11890973","cross_references":{"pubmed":["40059069"],"doi":["10.1111/irv.70081"]}}