{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng H"],"funding":["Sichuan Province Science and Technology Support Program","Sichuan Provincial Science and Technology Support Program","National Natural Science Foundation of China"],"pagination":["e70319"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11890974"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(3)"],"pubmed_abstract":["<h4>Background</h4>Previous observational studies have reported a possible association between major depressive disorder (MDD) and abnormal cortical structure. However, it is unclear whether MDD causes reductions in global cortical thickness (CT) and global area (SA).<h4>Objective</h4>We aimed to test the bidirectional causal relationship between MDD and CT and SA using a Mendelian randomization (MR) design and performed exploratory analyses of MDD on CT and SA in different brain regions.<h4>Methods</h4>Summary-level data were obtained from two GWAS meta-analysis studies: one screening for single nucleotide polymorphisms (SNPs) predicting the development of MDD (n = 135,458) and the other identifying SNPs predicting the magnitude of cortical thickness (CT) and surface area (SA) (n = 51,665"],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["Causal Association Between Major Depressive Disorder and Cortical Structure: A Bidirectional Mendelian Randomization Study and Mediation Analysis."],"pmcid":["PMC11890974"],"funding_grant_id":["2021JDTD0007","2022NSFSC1503","82274529"],"pubmed_authors":["Zheng H","Feng SJ","Chen M","Tang TC","Fang YJ","Wang XY"],"additional_accession":[]},"is_claimable":false,"name":"Causal Association Between Major Depressive Disorder and Cortical Structure: A Bidirectional Mendelian Randomization Study and Mediation Analysis.","description":"<h4>Background</h4>Previous observational studies have reported a possible association between major depressive disorder (MDD) and abnormal cortical structure. However, it is unclear whether MDD causes reductions in global cortical thickness (CT) and global area (SA).<h4>Objective</h4>We aimed to test the bidirectional causal relationship between MDD and CT and SA using a Mendelian randomization (MR) design and performed exploratory analyses of MDD on CT and SA in different brain regions.<h4>Methods</h4>Summary-level data were obtained from two GWAS meta-analysis studies: one screening for single nucleotide polymorphisms (SNPs) predicting the development of MDD (n = 135,458) and the other identifying SNPs predicting the magnitude of cortical thickness (CT) and surface area (SA) (n = 51,665","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-01T20:12:23.195Z","creation":"2025-04-07T07:49:31.372Z"},"accession":"S-EPMC11890974","cross_references":{"pubmed":["40059068"],"doi":["10.1111/cns.70319"]}}